Complete genome sequencing revealed novel genetic contexts of the mcr-1 gene in Escherichia coli strains
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkw541
Abstract: Sir, Polymyxin-based treatment is often considered as the last-line therapy for MDR Gram-negative bacterial infections. Resistance to polymyxins, in particular colistin, was previously linked to adaptive or mutational mechanisms involving chromosomally encoded genes before the… read more here.
Keywords: isapl1; dpap; mcr gene; resistance ... See more keywords
Loss of mcr Genes Mediated by Plasmid Elimination and ISApl1
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01002-19
Abstract: We characterized the stability of a plasmid pCP53-mcr1_3 encoding mcr-1 and mcr-3.19 with and without colistin exposure during cultural passages via S1-pulsed-field gel electrophoresis (PFGE) and nanopore MinION sequencing. Both mcr-1 and mcr-3.19 were missing… read more here.
Keywords: mcr; plasmid elimination; elimination; mcr mcr ... See more keywords