Biological perspective of a triazine derivative with isatin/chalcone/acridone: DFT and docking investigations
Sign Up to like & getrecommendations! Published in 2020 at "Structural Chemistry"
DOI: 10.1007/s11224-020-01609-6
Abstract: The article highlights insights into biological activity using computational methods in products of 1,3,5-triazine-2,4-diamine with 1H-indole-2,3-dione (isatin)/(2E)-13-diphenylprop-2-en-1-one (chalcone)/10H-acridin-9-one (acridone). Biological activity is carried out using the method of electron density, 6-311++G(d,p) for molecular and electronic… read more here.
Keywords: biological activity; isatin; biological perspective; acridone ... See more keywords
Azide-alkyne cycloaddition en route to ferrocenyl-methoxy-methyl-isatin-conjugates: Synthesis, anti-breast cancer activities and molecular docking studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2019.121072
Abstract: Abstract A series of 1H-1,2,3-triazole linked Ferrocenyl-methoxy-methyl-Isatin conjugates was synthesized and assayed for their anti-proliferative activities against estrogen-responsive as well as estrogen non-responsive cell lines. The non-cytotoxic conjugate 7l, with an optimum combination of octyl… read more here.
Keywords: isatin; methyl isatin; docking studies; isatin conjugates ... See more keywords
Green synthesis, antibacterial evaluation and QSAR analysis of some isatin Schiff bases
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.127853
Abstract: Abstract Twelve isatin Schiff bases (1a-7a, 1b-5b) were prepared by reacting isatin and 5-bromoisatin with different anilines using green chemistry (microwave (MW) and ultrasound (US) assisted synthesis). The antibacterial activity of each compound was evaluated… read more here.
Keywords: schiff bases; isatin; synthesis antibacterial; qsar analysis ... See more keywords
Isatin containing heterocycles for different biological activities: Analysis of structure activity relationship
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128900
Abstract: Abstract Isatin has been widely used in drug discovery. The ring is part of many naturally occurring compounds and is used to design compounds with diverse biological activities. These isatin containing heterocycles are active and… read more here.
Keywords: isatin containing; isatin; biological activities; structure ... See more keywords
Novel series of triazole containing coumarin and isatin based hybrid molecules as acetylcholinesterase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131085
Abstract: Abstract Novel series of coumarin-triazole and isatin-triazole hybrids were rationally designed, synthesized and biologically evaluated to check their inhibitory potential against acetylcholinesterase enzyme by using in vitro Ellman's method. Most of the hybrid compounds showed… read more here.
Keywords: acetylcholinesterase inhibitors; novel series; coumarin; series triazole ... See more keywords
Possible synergies between isatin, an endogenous MAO inhibitor, and antiparkinsonian agents on the dopamine release from striatum of freely moving rats.
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108083
Abstract: Isatin is an endogenous indole that inhibits monoamine oxidase (MAO). When exogenously administered, it increases the striatal dopamine and acetylcholine levels and presents neuroprotective effects in the brain. Previous studies show that intrastriatal administration of… read more here.
Keywords: isatin; administration isatin; isatin endogenous; dopamine release ... See more keywords
Isatin Detection Using a Boron-Doped Diamond 3-in-1 Sensing Platform.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b04045
Abstract: Boron-doped diamond (BDD) is a promising electrochemical tool that exhibits excellent chemical sensitivity and stability. These intrinsic advantages coupled with the material's vast microfabrication flexibility make BDD an attractive sensing device. In this study, two… read more here.
Keywords: doped diamond; detection; isatin; boron doped ... See more keywords
Zn(II)-catalysed enantioselective addition of alcohols and tert-butyl hydroperoxide to isatin-derived N-Boc ketimines.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01527k
Abstract: Using binaphthyl-proline-based chiral ligands, Zn(II)-catalysed addition of alcohols and tert-butyl hydroperoxide to isatin-derived N-Boc ketimines provided the isatin-derived C3 N,O-aminals in up to 99% yield and up to 99% ee. The reactions could be carried… read more here.
Keywords: butyl hydroperoxide; isatin; alcohols tert; addition alcohols ... See more keywords
Brain mitochondrial subproteome of Rpn10-binding proteins and its changes induced by the neurotoxin MPTP and the neuroprotector isatin
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297917030117
Abstract: Mitochondria play an important role in molecular mechanisms of neuroplasticity, adaptive changes of the brain that occur in the structure and function of its cells in response to altered physiological conditions or development of pathological… read more here.
Keywords: brain mitochondrial; rpn10 binding; isatin; binding proteins ... See more keywords
Synthesis, characterization, and anticancer activity of chitosan functionalized isatin based thiosemicarbazones, and their copper(II) complexes.
Sign Up to like & getrecommendations! Published in 2023 at "Carbohydrate research"
DOI: 10.2139/ssrn.4276240
Abstract: The one-pot synthetic method of condensation of isatin and 5-chloroisatin on to amino group at C2 position of the pyranose ring chitosan in chitosan thiosemicarbazide was employed to get these chitosan thiosemicarbazones (TSCs). The partial… read more here.
Keywords: anticancer activity; copper; isatin; chitosan tscs ... See more keywords
Tackling Microbial Resistance with Isatin-Decorated Thiazole Derivatives: Design, Synthesis, and in vitro Evaluation of Antimicrobial and Antibiofilm Activity
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s365909
Abstract: Introduction Antibiotic resistance is a global threat that has been increasing recently, especially with antibiotic overuse and misuse. The search for new antibiotics is becoming more and more indispensable. Methods Design and synthesis of isatin… read more here.
Keywords: design synthesis; antimicrobial antibiofilm; decorated thiazole; thiazole derivatives ... See more keywords