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Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900367
Abstract: The isatin framework is a useful template for the development of novel anticancer agents. This is exemplified by the fact that several isatin‐based anticancer agents, such as semaxanib, sunitinib, nintedanib, and hesperadin, are already in…
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Keywords:
based hybrids;
anticancer agents;
advances isatin;
recent advances ... See more keywords
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Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200164
Abstract: Three sets of isatin‐based Schiff bases were synthesized utilizing the molecular hybridization approach. Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell…
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Keywords:
schiff bases;
qsar studies;
vegfr inhibition;
based schiff ... See more keywords
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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.11.008
Abstract: In an attempt to develop new antimalarial drugs, we have synthesized a new class of N-alkylated 3-glycoconjugated-oxopropylidene oxindoles starting from substituted isatins and glucopyranosyl propanone via a well-known cross-aldol reaction followed by dehydration. The newly…
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Keywords:
glycoconjugated oxopropylidene;
synthesis isatin;
based alkylated;
oxopropylidene oxindoles ... See more keywords
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Published in 2019 at "New Journal of Chemistry"
DOI: 10.1039/c9nj00405j
Abstract: Cooperative H-bonding and antiparallel π–π interactions in crystal structures of isatin derivatives are investigated using X-ray crystallography and DFT calculations.
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Keywords:
interactions solid;
isatin based;
state isatin;
solid state ... See more keywords
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Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00297g
Abstract: Recently, scientists developed a powerful strategy called “one drug-multiple targets” to discover vital and unique therapies to fight the most challenging diseases. Novel derivatives of isatin-based Schiff bases 2–7 have been synthesized by the reaction…
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Keywords:
schiff bases;
derivatives isatin;
based schiff;
isatin based ... See more keywords
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Published in 2023 at "Carbohydrate research"
DOI: 10.2139/ssrn.4276240
Abstract: The one-pot synthetic method of condensation of isatin and 5-chloroisatin on to amino group at C2 position of the pyranose ring chitosan in chitosan thiosemicarbazide was employed to get these chitosan thiosemicarbazones (TSCs). The partial…
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Keywords:
anticancer activity;
copper;
isatin;
chitosan tscs ... See more keywords