Organocatalytic asymmetric [3 + 3] annulation of isatin N,N'-cyclic azomethine imines with enals: Efficient approach to functionalized spiro N-heterocyclic oxindoles
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DOI: 10.1016/j.cclet.2020.06.010
Abstract: Abstract An unprecedented chiral secondary amine-catalyzed [3 + 3] annulation of isatin N,N'-cyclic azomethine imines with α,β-unsaturated aldehydes was developed. This strategy allowed the construction of structurally novel spiro N-heterocyclic oxindole derivatives in good yields (up to… read more here.
Keywords: cyclic azomethine; isatin cyclic; azomethine imines; spiro heterocyclic ... See more keywords
Rapid abnormal [3+2]-cycloaddition of isatin N,N′-cyclic azomethine imine 1,3-dipoles with chalcones
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DOI: 10.1039/d0nj00887g
Abstract: The rapid synthesis of novel dicyclic spiropyrrolidine was reported, using [3+2]-cycloaddition of isatin N,N′-cyclic azomethine imine 1,3-dipoles, generated from the condensation of substituted isatins and pyrazolidones, with chalcones in 2–5 min. The dicyclic spiropyrrolidine oxoindole… read more here.
Keywords: cyclic azomethine; isatin cyclic; azomethine imine; imine dipoles ... See more keywords