Synthesis and Phytotoxic Evaluation of Isatin Derivatives Supported by 3D-QSAR Study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c06500
Abstract: Concerned about weed infestation, a major threat to food production and herbicide resistance that interferes in the mechanism of action of the main herbicides, we have synthesized eight isatin derivatives using the "Click Chemistry" approach… read more here.
Keywords: synthesis phytotoxic; chemistry; isatin derivatives; activity ... See more keywords
New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2110869
Abstract: Abstract New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed comparable… read more here.
Keywords: new quinoline; quinoline isatin; isatin derivatives; activity ... See more keywords
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2203389
Abstract: Abstract In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer activities. Firstly, all target isatins were examined for in vitro antitumor… read more here.
Keywords: discovery sulfonamide; sulfonamide tethered; isatin derivatives; derivatives novel ... See more keywords
Abstract 2806: Inhibition of melanoma development by Isatin analogs
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2806
Abstract: Despite major breakthroughs in melanoma drug development, there remains a need for new drugs and novel approaches. Of the three forms of skin cancer, malignant melanoma has the most significant impact on human health carrying… read more here.
Keywords: melanoma; inhibition melanoma; cancer; development ... See more keywords
Synthesis of isatin and its derivatives having antibacterial, antifungal and cytotoxic activities.
Sign Up to like & getrecommendations! Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179419666220128091313
Abstract: OBJECTIVE The current objective was to synthesize biologically active Isatin derivatives. For this purpose, six (06) chemical entities of Isatin derivatives such as 3a-3c and 4a-4c were synthesized from Isatin substrate. METHODS The pure compounds… read more here.
Keywords: antibacterial antifungal; cytotoxic activities; isatin derivatives; compound ... See more keywords
In Vitro Cytotoxicity and Apoptosis Inducing Evaluation of Novel Halogenated Isatin Derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220119091642
Abstract: BACKGROUND Isatin (1H-indole-2,3-dione) and its derivatives have been shown their responsibility in a wide range of biological activities. Among the range of beneficial properties, anticancer compounds were the most extensively highlighted and explored. OBJECTIVE Herein,… read more here.
Keywords: halogenated isatin; apoptosis; vitro cytotoxicity; novel ... See more keywords
Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.627272
Abstract: In this review we compare and discuss results of compounds already reported as anticancer agents based on isatin-derivatives, metalated as well as non-metallated. Isatin compounds can be obtained from plants, marine animals, and is also… read more here.
Keywords: anticancer compounds; based isatin; isatin derivatives; compounds based ... See more keywords
Designing and Synthesis of New Isatin Derivatives as Potential CDK2 Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23148046
Abstract: Tumors are still one of the main causes of death; therefore, the search for new therapeutic agents that will enable the implementation of effective treatment is a significant challenge for modern pharmacy. One of the… read more here.
Keywords: isatin; derivatives potential; isatin derivatives; new isatin ... See more keywords
Synthesis and Antiproliferatory Activities Evaluation of Multi-Substituted Isatin Derivatives
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DOI: 10.3390/molecules26010176
Abstract: A series of multi-substituted isatin derivatives were synthesized using the powerful Sandmeyer reaction. The structures of these derivatives were confirmed by 1H-NMR, 13C-NMR, and HR-MS. Inhibition of proliferation activities of these derivatives against human leukemia… read more here.
Keywords: activities evaluation; antiproliferatory activities; substituted isatin; multi substituted ... See more keywords
Investigations on Anticancer Potentials by DNA Binding and Cytotoxicity Studies for Newly Synthesized and Characterized Imidazolidine and Thiazolidine-Based Isatin Derivatives
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DOI: 10.3390/molecules27020354
Abstract: Imidazolidine and thiazolidine-based isatin derivatives (IST-01–04) were synthesized, characterized, and tested for their interactions with ds-DNA. Theoretical and experimental findings showed good compatibility and indicated compound–DNA binding by mixed mode of interactions. The evaluated binding… read more here.
Keywords: cell; based isatin; dna binding; imidazolidine thiazolidine ... See more keywords
3D-QSAR Studies of Isatin Derivatives with Anti-Cancer In Vitro: AdvancedCoMFA, CoMSIA and Docking Methods
Sign Up to like & getrecommendations! Published in 2017 at "Chemical Science"
DOI: 10.4172/2150-3494.1000158
Abstract: Three-dimensional quantitative structure–activity relationship (3D-QSAR) and docking methods were performed to study 47 tubulin inhibitors, isatin derivatives with anticancer activity against human monocyte-like histiocytic lymphoma human U937 cells. The established 3D-QSAR model from Comparative Molecular… read more here.
Keywords: derivatives anti; comsia; docking methods; studies isatin ... See more keywords