Gatifloxacin‐1,2,3‐triazole‐isatin hybrids and their antimycobacterial activities
Sign Up to like & getrecommendations! Published in 2019 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201900135
Abstract: A series of gatifloxacin‐1,2,3‐triazole‐isatin hybrids 8a–l were designed, synthesized, and screened for their in vitro antimycobacterial activity as well as cytotoxicity toward Chinese Hamster Ovary (CHO) cells. The synthesized hybrids showed considerable activity against MTB… read more here.
Keywords: hybrids antimycobacterial; isatin hybrids; antimycobacterial activities; gatifloxacin triazole ... See more keywords
Repositioning of Isatin hybrids as novel anti-tubercular agents overcoming pre-existing antibiotics resistance
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DOI: 10.1007/s00044-021-02699-5
Abstract: The widespread deaths of tuberculosis from many decades demands an urgent need for the development of novel anti-tubercular scaffolds that are more potent and highly selective with lower cytotoxicity. Isatin hybrids are endowed with an… read more here.
Keywords: novel anti; anti tubercular; hybrids novel; repositioning isatin ... See more keywords
Dihydropyrimidinone-isatin hybrids as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
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DOI: 10.1016/j.bioorg.2017.01.006
Abstract: A novel series of substituted N-(2-(2,3-dioxoindolin-1-yl)acetyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide was designed, synthesized and evaluated for in vitro Reverse Transcriptase (RT) inhibitory activity. This series is a combination of peculiar structural features from leading scaffolds of [(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT) and… read more here.
Keywords: isatin hybrids; hybrids novel; reverse; reverse transcriptase ... See more keywords
Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids.
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DOI: 10.1016/j.ejmech.2018.07.025
Abstract: Twelve novel propylene-tethered ciprofloxacin-isatin hybrids 3a-f and 4a-f were designed, synthesized and characterized by MS, HRMS, 1H NMR and 13C NMR. All hybrids were evaluated for their in vitro antimicrobial activities against representative Gram-positive, Gram-negative and… read more here.
Keywords: isatin hybrids; propylene tethered; gram; tethered ciprofloxacin ... See more keywords
Synthesis and studies of thiazolidinedione-isatin hybrids as α-glucosidase inhibitors for management of diabetes.
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DOI: 10.4155/fmc-2020-0022
Abstract: Aim: Keeping in view the side effects associated with clinically used α-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures. Materials & methods: Biological evaluation, cytotoxicity assessment,… read more here.
Keywords: synthesis studies; isatin hybrids; studies thiazolidinedione; glucosidase inhibitors ... See more keywords