Ciprofloxacin‐isatin‐1H‐1,2,3‐triazole Hybrids: Design, Synthesis, and in vitro Anti‐tubercular Activity against M. tuberculosis
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DOI: 10.1002/jhet.3010
Abstract: A new set of ciprofloxacin (CPFX)-isatin-1H-1,2,3-triazole hybrids 6a–l with greater lipophilicity compared with the parent CPFX was designed, synthesized, and assessed for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis (MTB) H37Rv as well as… read more here.
Keywords: isatin triazole; triazole hybrids; vitro anti; ciprofloxacin ... See more keywords
Novel isatin-triazole based thiosemicarbazones as potential anticancer agents: synthesis, DFT and molecular docking studies.
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DOI: 10.1039/d4ra01937g
Abstract: Thiosemicarbazones of isatin have been found to exhibit versatile bioactivities. In this study, two distinct types of isatin-triazole hybrids 3a and 3b were accessed via copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC), together with their mono and… read more here.
Keywords: molecular docking; docking studies; anticancer; isatin triazole ... See more keywords
Design and development of an isatin-1,2,3-triazole hybrid analogue as a potent anti-inflammatory agent with enhanced efficacy and gene expression modulation
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DOI: 10.1039/d4ra07294d
Abstract: Isatin (1H-indole-2,3-dione) and its derivatives have been found to exhibit various biological activities, including anticancer and antidiabetic properties. In this study, a series of nine isatin-1,2,3-triazole conjugates were synthesized and evaluated for their anti-inflammatory potential… read more here.
Keywords: fold fold; gene expression; isatin triazole; isatin ... See more keywords