Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2020.112071
Abstract: Abstract From an aqueous decoction of the traditional Chinese medicine “ban lan gen” (the Isatis indigotica root), an antiviral natural product CI - 39 was isolated as an NNRTI (non-nucleoside reverse transcriptase inhibitor) (EC50 = 3.40 μM). Its novel structure… read more here.
Keywords: discovery synthesis; isatis indigotica; indigotica root; nnrti resistant ... See more keywords
Alkaloids with neuroprotective effects from the leaves of Isatis indigotica collected in the Anhui Province, China.
Sign Up to like & getrecommendations! Published in 2018 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2018.02.016
Abstract: Six undescribed alkaloids, indiforine A-F, together with four known ones, were isolated from the leaves of Isatis indigotica Fortune. Their structures were elucidated on the basis of extensive spectroscopic analyses. The absolute configurations of indiforine… read more here.
Keywords: isatis indigotica; neuroprotective effects; leaves isatis; indigotica collected ... See more keywords
Effects of water saving and nitrogen reduction on the yield, quality, water and nitrogen use efficiency of Isatis indigotica in Hexi Oasis
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-021-04585-x
Abstract: Isatis indigotica planting is the backbone of the medicinal industry in Hexi Oasis, Gansu. In order to solve the problems insufficient water resources and excessive application of nitrogen fertilizer in this area, this paper explored… read more here.
Keywords: isatis indigotica; water; application; nitrogen ... See more keywords
Sulfonated alkaloids from an aqueous extract of Isatis indigotica roots
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asian Natural Products Research"
DOI: 10.1080/10286020.2022.2064284
Abstract: Abstract Eleven new sulfonated alkaloids (1 − 11) having diverse structures were isolated from an aqueous extract of the Isatis indigotica root (ban lan gen). Their structures were determined by spectroscopic data analysis, chemical method, and theoretical… read more here.
Keywords: aqueous extract; isatis indigotica; sulfonated alkaloids; extract isatis ... See more keywords
Functional identification of the different regions in B-class floral homeotic MADS-box proteins IiAP3 and IiPI from Isatis indigotica.
Sign Up to like & getrecommendations! Published in 2022 at "Physiologia plantarum"
DOI: 10.1111/ppl.13713
Abstract: APETALA3 (AP3) and PISTILLATA (PI) are B-class MADS-box floral homeotic genes of Arabidopsis and are involved in specifying the identity of petals and stamens. In the present work, IiAP3 and IiPI, the respective orthologous genes… read more here.
Keywords: isatis indigotica; iiap3 iipi; class; mads box ... See more keywords
Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00078
Abstract: Stress has been proven to modulate an individual’s immune system through the release of pituitary and adrenal hormones such as the catecholamines, growth hormone, and glucocorticoids. These signal molecules can significantly alter the host immune… read more here.
Keywords: isatis indigotica; alkaloid isatis; infection; model ... See more keywords
Tandem UGT71B5s Catalyze Lignan Glycosylation in Isatis indigotica With Substrates Promiscuity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.637695
Abstract: Lignans are a class of chemicals formed by the combination of two molecules of phenylpropanoids with promising nutritional and pharmacological activities. Lignans glucosides, which are converted from aglycones catalyzed by uridine diphosphate (UDP) glycosyltransferases (UGTs),… read more here.
Keywords: indigotica; isatis indigotica; tandem ugt71b5s; glycosylation ... See more keywords
Identification and investigation of a novel NADP+-dependent secoisolariciresinol dehydrogenase from Isatis indigotica
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1035121
Abstract: Cofactors are crucial for the biosynthesis of natural compounds, and cofactor engineering is a useful strategy for enzyme optimization due to its potential to enhance enzyme efficiency. Secoisolariciresinol dehydrogenase (SIRD) was reported to convert secoisolariciresinol… read more here.
Keywords: cofactor; isatis indigotica; secoisolariciresinol dehydrogenase;
Alkaloid Enantiomers from the Roots of Isatis indigotica
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DOI: 10.3390/molecules24173140
Abstract: Five pairs of alkaloid enantiomers (1a/1b–5a/5b) were obtained from Isatis indigotica (I. indigotica) roots. Among them, 1a/1b, 2a/2b and 3a/3b were determined as three pairs of new alkaloid enantiomers. Their structures were elucidated by physicochemical… read more here.
Keywords: alkaloid enantiomers; isatis indigotica; roots isatis; enantiomers roots ... See more keywords
SEPALLATA-like genes of Isatis indigotica can affect the architecture of the inflorescences and the development of the floral organs
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.13034
Abstract: Background The architecture of inflorescence and the development of floral organs can influence the yield of seeds and have a significant impact on plant propagation. E-class floral homeotic MADS-box genes exhibit important roles in regulation… read more here.
Keywords: development floral; architecture inflorescences; isatis indigotica; floral organs ... See more keywords