MicroRNA-19b-1 reverses ischaemia-induced heart failure by inhibiting cardiomyocyte apoptosis and targeting Bcl2 l11/BIM
Sign Up to like & getrecommendations! Published in 2018 at "Heart and Vessels"
DOI: 10.1007/s00380-018-01336-3
Abstract: Ischaemia induces cardiac apoptosis and leads to a loss of cardiac function and heart failure after myocardial infarction. MicroRNA-19b-1 (miR-19b-1), a key member of the miR-17/92 cluster, plays crucial roles in inhibiting apoptosis. However, the… read more here.
Keywords: heart; apoptosis; mir 19b; heart failure ... See more keywords
Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart
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DOI: 10.1038/s41598-020-65190-y
Abstract: The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally undertaken separately. Our… read more here.
Keywords: index; translational therapeutic; ischaemia induced; mexiletine ... See more keywords
Fullerenol nanoparticles decrease ischaemia-induced brain injury and oedema through inhibition of oxidative damage and aquaporin-1 expression in ischaemic stroke
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DOI: 10.1080/02699052.2017.1300835
Abstract: ABSTRACT Background: We examined the possible protective effects of fullerenol nanoparticles on brain injuries and oedema in experimental model of ischaemic stroke through inhibition of oxidative damage and aquaporin-1 (AQP-1) expression. Methods: Experiment was done… read more here.
Keywords: induced brain; oxidative damage; inhibition oxidative; ischaemic stroke ... See more keywords
Facilitation of ischaemia‐induced ventricular fibrillation by catecholamines is mediated by β1 and β2 agonism in the rat heart in vitro
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DOI: 10.1111/bph.14176
Abstract: Antiarrhythmic β‐blockers are used in patients at risk of myocardial ischaemia, but the survival benefit and mechanisms are unclear. We hypothesized that β‐blockers do not prevent ventricular fibrillation (VF) but instead inhibit the ability of… read more here.
Keywords: facilitation ischaemia; ischaemia; ischaemia induced; induced ventricular ... See more keywords