miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes
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DOI: 10.1038/s41598-024-65373-x
Abstract: Ischemic heart diseases are a major global cause of death, and despite timely revascularization, heart failure due to ischemia-hypoxia reperfusion (IH/R) injury remains a concern. The study focused on the role of Early Growth Response… read more here.
Keywords: hypoxia reperfusion; ischemia hypoxia; reperfusion injury; egr1 ... See more keywords
Pigment Epithelium-Derived Factor Protects Retinal Neural Cells and Prevents Pathological Angiogenesis in an Ex Vivo Ischemia Model
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DOI: 10.1155/2022/4199394
Abstract: Ocular ischemia/hypoxia is a severe problem in ophthalmology that can cause vision impairment and blindness. However, little is known about the changes occurring in the existing fully formed choroidal blood vessels. We developed a new… read more here.
Keywords: ischemia; ischemia hypoxia; pigment epithelium; pathological angiogenesis ... See more keywords
Abstract WP261: Dcr1 and Dcr2 Protect Neuron Against Ischemia and Hypoxia Damage via Differential Mechanisms on Ischemia Preconditioning-Induced Neuroprotection
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DOI: 10.1161/str.49.suppl_1.wp261
Abstract: Objective: To investigate the neuroprotective roles and mechanisms of DcR1 and DcR2 under ischemia and hypoxia. Methods: SH-SY5Y cell were used to build to oxygen glucose deprivation model (OGD) an... read more here.
Keywords: abstract wp261; dcr1 dcr2; ischemia hypoxia; wp261 dcr1 ... See more keywords
Enhancement of Mitochondrial Homeostasis: A Novel Approach to Attenuate Hypoxic Myocardial Injury
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DOI: 10.7150/ijms.103986
Abstract: Cardiomyocytes are highly oxygen-dependent cells, relying on oxygen-driven oxidative phosphorylation to maintain their function. During hypoxia, mitochondrial ATP production decreases, leading to calcium overload, acidosis, and oxidative stress, which collectively trigger myocardial injury. Ischemic heart… read more here.
Keywords: ischemia hypoxia; reperfusion injury; myocardial injury; mitochondrial homeostasis ... See more keywords