Melatonin suppresses ischemia-induced fibrosis by regulating miR-149.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.02.090
Abstract: Ischemic injury is a major risk factor for fibrosis. However, the precise mechanisms by which fibrosis is regulated and induced under ischemic oxidative stress conditions are unknown. To address this, we investigated the effect of… read more here.
Keywords: fibrosis; mir 149; ischemia induced; melatonin ... See more keywords
Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.03.066
Abstract: Background We previously demonstrated the gut microbes-derived metabolite trimethylamine N-oxide (TMAO) could activate the atrial autonomic ganglion plexus and promote atrial arrhythmia. The cardiac sympathetic nervous system (CSNS) play important roles in modulating ventricular arrhythmia… read more here.
Keywords: arrhythmia; nervous system; tmao; derived metabolite ... See more keywords
Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.113117
Abstract: Previous studies have shown that simvastatin (Sim) has neuroprotective effects in a neonatal model of hypoxia-ischemia (HI)-induced brain injury when administered before but not after HI, pointing to the preconditioning (PC)-like effects of the statin.… read more here.
Keywords: sirt1; induced brain; hypoxia ischemia; ischemia induced ... See more keywords
Methanol extract of Ficus platyphylla decreases cerebral ischemia induced injury in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2021.114219
Abstract: ETHNOPHARMACOLOGICAL Relevance Extracts of the stem bark of Ficus paltyphylla (FP) are used in the Nigerian traditional medicine to manage psychoses, depression, epilepsy, pain, and inflammation. Our previous studies revealed that the methanol extract of… read more here.
Keywords: ficus; methanol extract; cerebral ischemia; ischemia ... See more keywords
Inhibitions of PKC and CaMK-II synergistically rescue ischemia-induced astrocytic dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.08.017
Abstract: Ischemic neuronal death is presumably caused by glutamate-induced excitotoxicity, in which the increased glutamate release and impaired glutamate reuptake lead to glutamate accumulation. Mechanisms underlying the ischemic deficiency of astrocytic glutamate reuptake remain unclear, which… read more here.
Keywords: glutamate; astrocytic glutamate; ischemia induced; deficiency ... See more keywords
PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-0812-7
Abstract: Microvascular pathology and ischemic lesions contribute substantially to neuronal dysfunction and loss that lead to Alzheimer disease (AD). To facilitate recovery, the brain stimulates neovascularization of damaged tissue via sprouting angiogenesis, a process regulated by… read more here.
Keywords: fad mutants; brain; ischemia induced; ps1 fad ... See more keywords
Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study.
Sign Up to like & getrecommendations! Published in 2017 at "Chaos"
DOI: 10.1063/1.5002664
Abstract: Ischemia in the heart impairs function of the cardiac pacemaker, the sinoatrial node (SAN). However, the ionic mechanisms underlying the ischemia-induced dysfunction of the SAN remain elusive. In order to investigate the ionic mechanisms by… read more here.
Keywords: cardiac pacemaking; study; ischemia; simulation ... See more keywords
Modulation of cGAS-STING signaling by PPARα in a mouse model of ischemia-induced retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208934119
Abstract: Significance Ischemic retinopathy is a leading cause of blindness and has unmet medical needs for novel therapeutic strategies. In this work, we found that the cGAS-STING pathway was activated in the retina with ischemia-induced retinopathy,… read more here.
Keywords: ischemia induced; ppar; sting signaling; induced retinopathy ... See more keywords
A bone morphogenetic protein signaling inhibitor, LDN193189, converts ischemia-induced multipotent stem cells into neural stem/progenitor cell-like cells.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells and development"
DOI: 10.1089/scd.2022.0139
Abstract: Stem cell therapy is used to restore neurological function in stroke patients. We have previously reported that ischemia-induced multipotent stem cells (iSCs), which are likely derived from brain pericytes, develop in post-stroke human and mouse… read more here.
Keywords: ischemia induced; multipotent stem; induced multipotent; iscs ... See more keywords
Transplantation of Human Brain-Derived Ischemia-Induced Multipotent Stem Cells Ameliorates Neurological Dysfunction in Mice After Stroke.
Sign Up to like & getrecommendations! Published in 2023 at "Stem cells translational medicine"
DOI: 10.1093/stcltm/szad031
Abstract: We recently demonstrated that injury/ischemia-induced multipotent stem cells (iSCs) develop within post-stroke human brains. Because iSCs are stem cells induced under pathological conditions, such as ischemic stroke, the use of human brain-derived iSCs (h-iSCs) may… read more here.
Keywords: ischemia induced; induced multipotent; transplantation; stem ... See more keywords
Role of glycogen synthase kinase 3 in ischemia‐induced blood–brain barrier disruption in aged female rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14051
Abstract: Estrogen receptors have protective effects against ischemic brain injury. However, the molecular mechanisms underlying this phenomenon have yet to be well studied. Given that inhibition of glycogen synthase kinase (GSK3) can reduce cerebral ischemia/reperfusion injury,… read more here.
Keywords: disruption; expression; ischemia induced; brain ... See more keywords