An Injectable Dual-Function Hydrogel Protects Against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium.
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DOI: 10.1002/advs.202105408
Abstract: Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective strategy for treating MI due to the multiple… read more here.
Keywords: ischemia reperfusion; reperfusion injury; injury; function ... See more keywords
Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis
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DOI: 10.1002/advs.202204697
Abstract: Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic acid (3‐HAA) and quinolinic… read more here.
Keywords: kynurenine pathway; reperfusion injury; exacerbates liver; hepatic ischemia ... See more keywords
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury
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DOI: 10.1002/advs.202205436
Abstract: Ferroptosis has been linked to the pathogenesis of hepatic injury induced by ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by using a mouse model of hepatic I/R injury, it is observed… read more here.
Keywords: malic enzyme; me1; injury; ischemia reperfusion ... See more keywords
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)
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DOI: 10.1002/advs.202370079
Abstract: Malic Enzyme 1 In article number 2205436, Xuexian Fang, Fudi Wang, and co‐workers discover Malic Enzyme 1 (ME1) as a novel ferroptosis inhibitory gene, which protects the liver function against ischemia/reperfusion (I/R) injury. The design… read more here.
Keywords: reperfusion injury; ischemia reperfusion; injury; malic enzyme ... See more keywords
Ticagrelor reduces myocardial cell injury induced by myocardial ischemia-reperfusion in diabetic rats by activating JAK2/STAT3.
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DOI: 10.1002/cbin.11940
Abstract: The treatment of diabetic patients with myocardial infarction is still full of challenges. Diabetes may exacerbate myocardial ischemia/reperfusion (I/R) injury. Ticagrelor alleviates I/R injury. However, the protective effects of ticagrelor on the diabetic myocardium following… read more here.
Keywords: diabetic rats; ticagrelor; myocardial ischemia; jak2 stat3 ... See more keywords
TNFAIP3 Interacting Protein 3 Is an Activator of Hippo‐YAP Signaling Protecting Against Hepatic Ischemia/Reperfusion Injury
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DOI: 10.1002/hep.32015
Abstract: Hepatic ischemia/reperfusion (I/R) injury, a common clinical problem that occurs during liver surgical procedures, causes a large proportion of early graft failure and organ rejection cases. The identification of key regulators of hepatic I/R injury… read more here.
Keywords: interacting protein; ischemia reperfusion; reperfusion injury; injury ... See more keywords
PAK4 inhibition protects against liver ischemia/reperfusion injury: Role of Nrf2 phosphorylation.
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DOI: 10.1002/hep.32384
Abstract: BACKGROUND & AIMS p21 activated kinase 4 (PAK4), an oncogenic protein, has emerged as a promising target for anti-cancer drug development. Its role in oxidative stress conditions, however, remains elusive. We investigated the effects of… read more here.
Keywords: pak4; ischemia reperfusion; reperfusion injury; injury ... See more keywords
Inhibited histone deacetylase 3 ameliorates myocardial ischemia–reperfusion injury in a rat model by elevating microRNA‐19a‐3p and reducing cyclin‐dependent kinase 2
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DOI: 10.1002/iub.2402
Abstract: Over the years, the roles of microRNAs (miRNAs) and histone deacetylase 3 (HDAC3) in human diseases have been investigated. This study focused on the effect of miR‐19a‐3p and HDAC3 in myocardial ischemia–reperfusion (I/R) injury (MIRI)… read more here.
Keywords: cyclin dependent; myocardial ischemia; histone deacetylase; dependent kinase ... See more keywords
LncRNA CHRF aggravates myocardial ischemia/reperfusion injury by enhancing autophagy via modulation of the miR‐182‐5p/ATG7 pathway
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DOI: 10.1002/jbt.22709
Abstract: Myocardial ischemia/reperfusion (I/R) injury is a very frequent cardiovascular disease and one of the leading causes of death. Abundant evidence has shown that long noncoding RNAs (lncRNAs) are crucial players in myocardial I/R injury. LncRNA… read more here.
Keywords: mir 182; chrf; myocardial injury; myocardial ischemia ... See more keywords
Eprosartan: A closer insight into its neuroprotective activity in rats with focal cerebral ischemia–reperfusion injury
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DOI: 10.1002/jbt.22796
Abstract: Eprosartan (EPRO), an angiotensin receptor type‐1 (AT‐1) blocker, exhibited neuroprotective activities in ischemic stroke resulting from focal cerebral ischemia in rats. The current study aimed to clarify the neuroprotective role of EPRO in middle carotid… read more here.
Keywords: cerebral ischemia; group; focal cerebral; ischemia ... See more keywords
The protective effects of propofol against renal ischemia-reperfusion injury are potentiated by norisoboldine treatment via inhibition of oxidative stress pathways.
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DOI: 10.1002/jbt.22937
Abstract: Acute kidney injury (AKI) is a significant worldwide health problem. The protective effects of norisoboldine (NOR) against ischemia/reperfusion (I/R) induced renal injury in a rat model were evaluated. AKI was induced in rats by I/R.… read more here.
Keywords: treatment; ischemia reperfusion; injury; protective effects ... See more keywords