Remodeling the Neuroimmune Microenvironment in Retinal Ischemia‐Reperfusion Injury via Combined CRISPR/Cas9 Targeting of ACSL4 and Isorhamnetin
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DOI: 10.1002/adfm.202505041
Abstract: Retinal ischemia‐reperfusion (RIR) injury induces oxidative stress, excitotoxicity, inflammation, and ferroptosis, which interact through complex crosstalk, forming a retinal pathological microenvironment (RPMe) that drives retinal ganglion cell (RGC) death. Central to these processes is the… read more here.
Keywords: neuroimmune microenvironment; retinal ischemia; ischemia reperfusion; crispr cas9 ... See more keywords
Ultrasmall Nanoparticles Regulate Immune Microenvironment by Activating IL‐33/ST2 to Alleviate Renal Ischemia‐Reperfusion Injury
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DOI: 10.1002/adhm.202303276
Abstract: Renal ischemia‐reperfusion injury (IRI) is a common disease with high morbidity and mortality. Renal IRI can cause the disorder of immune microenvironment and reprograming the immune microenvironment to alleviate excessive inflammatory response is crucial for… read more here.
Keywords: renal ischemia; ischemia reperfusion; iri; microenvironment ... See more keywords
Lycium Barbarum Polysaccharide‐Derived Nanoparticles Protect Visual Function by Inhibiting RGC Ferroptosis and Microglial Activation in Retinal Ischemia‒Reperfusion Mice
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DOI: 10.1002/adhm.202304285
Abstract: Retinal ischemia‒reperfusion (IR) is a major contributor to vision impairment and irreversible vision loss due to retinal ganglion cell (RGC) injury or loss. Contemporary therapeutic approaches predominantly focus on the amelioration of symptoms rather than… read more here.
Keywords: retinal ischemia; ischemia reperfusion; lycium barbarum; barbarum polysaccharide ... See more keywords
Polymer‐Conjugated SOD‐Pt⁰ Micelles Enhance ROS Cascade Scavenging to Alleviate Ischemia‐Reperfusion Injury During Kidney Transplantation
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DOI: 10.1002/adhm.202500696
Abstract: Ischemia‐reperfusion injury (IRI) during kidney transplantation is linked to oxidative stress induced by excessive reactive oxygen species (ROS), which causes the injury of transplanted kidney, leading to further intensified organ shortages. Protein‐based antioxidants have been… read more here.
Keywords: kidney transplantation; ischemia reperfusion; reperfusion injury; injury ... See more keywords
An Injectable Dual-Function Hydrogel Protects Against Myocardial Ischemia/Reperfusion Injury by Modulating ROS/NO Disequilibrium.
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DOI: 10.1002/advs.202105408
Abstract: Acute myocardial infarction (MI) is the leading cause of death worldwide. Exogenous delivery of nitric oxide (NO) to the infarcted myocardium has proven to be an effective strategy for treating MI due to the multiple… read more here.
Keywords: ischemia reperfusion; reperfusion injury; injury; function ... See more keywords
Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia–Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis
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DOI: 10.1002/advs.202204697
Abstract: Hepatic ischemia–reperfusion (IR) injury remains a common issue lacking effective strategy and validated pharmacological targets. Here, using an unbiased metabolomics screen, this study finds that following murine hepatic IR, liver 3‐hydroxyanthranilic acid (3‐HAA) and quinolinic… read more here.
Keywords: kynurenine pathway; reperfusion injury; exacerbates liver; hepatic ischemia ... See more keywords
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury
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DOI: 10.1002/advs.202205436
Abstract: Ferroptosis has been linked to the pathogenesis of hepatic injury induced by ischemia/reperfusion (I/R). However, the mechanistic basis remains unclear. In this study, by using a mouse model of hepatic I/R injury, it is observed… read more here.
Keywords: malic enzyme; me1; injury; ischemia reperfusion ... See more keywords
A Membrane‐Targeting Aggregation‐Induced Emission Probe for Monitoring Lipid Droplet Dynamics in Ischemia/Reperfusion‐Induced Cardiomyocyte Ferroptosis
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DOI: 10.1002/advs.202309907
Abstract: Myocardial ischemia/reperfusion injury (MIRI) is the leading cause of irreversible myocardial damage. A pivotal pathogenic factor is ischemia/reperfusion (I/R)‐induced cardiomyocyte ferroptosis, marked by iron overload and lipid peroxidation. However, the impact of lipid droplet (LD)… read more here.
Keywords: ischemia reperfusion; reperfusion; induced cardiomyocyte; ferroptosis ... See more keywords
Malic Enzyme 1 as a Novel Anti‐Ferroptotic Regulator in Hepatic Ischemia/Reperfusion Injury (Adv. Sci. 13/2023)
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DOI: 10.1002/advs.202370079
Abstract: Malic Enzyme 1 In article number 2205436, Xuexian Fang, Fudi Wang, and co‐workers discover Malic Enzyme 1 (ME1) as a novel ferroptosis inhibitory gene, which protects the liver function against ischemia/reperfusion (I/R) injury. The design… read more here.
Keywords: reperfusion injury; ischemia reperfusion; injury; malic enzyme ... See more keywords
TRIM56 Aggravates Cerebral Ischemia-Reperfusion Injury via Inhibiting KLF4-Activated Ferroptosis Signaling.
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DOI: 10.1002/advs.202509906
Abstract: Cerebral ischemia-reperfusion (I/R) injury often causes significant neuronal damage, neurological deficits, and long-term disability. This study investigates the role of tripartite motif-protein 56 (TRIM56) in cerebral I/R injury and elucidates the underlying mechanisms. Here, a… read more here.
Keywords: ischemia reperfusion; trim56; cerebral ischemia; reperfusion injury ... See more keywords
Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia-Reperfusion Injury.
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DOI: 10.1002/advs.202516001
Abstract: Even after successful revascularization in acute ischemic stroke, some patients still develop secondary neuronal damage and functional impairment, known as cerebral ischemia-reperfusion injury (CIRI). The complex pathophysiological cascade within CIRI limits the efficacy of current… read more here.
Keywords: mxene nanozymes; ischemia reperfusion; cerebral ischemia; reperfusion injury ... See more keywords