Soluble epoxide hydrolase inhibitors might prevent ischemic arrhythmias via microRNA-1 repression in primary neonatal mouse ventricular myocytes.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c6mb00824k
Abstract: Ischemic arrhythmias are the main causes of sudden cardiac death. It has been reported that soluble epoxide hydrolase inhibitors (sEHis) could prevent arrhythmias; however, the underlying molecular mechanisms remain unclear. In recent years, the proarrhythmic… read more here.
Keywords: soluble epoxide; hydrolase inhibitors; epoxide hydrolase; mir ... See more keywords
The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0177600
Abstract: Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier potassium current (IK1) in cardiomyocytes. However, clinical anti-arrhythmic agents that primarily act on RMP by… read more here.
Keywords: kir2; acute ischemic; prevents cures; ischemic arrhythmias ... See more keywords