Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09805-6
Abstract: Nicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a… read more here.
Keywords: adenine dinucleotide; emerges therapeutic; ischemic conditions; nicotinamide adenine ... See more keywords
Cardiac Electromechanical Coupling Model of Myocardial Contractile Function under Ischemic Conditions
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.578
Abstract: Hyperkalemia, acidosis, and anoxia are major pathophysiological conditions of myocardial ischemia. Cardiac arrhythmias induced by these conditions are widely investigated. However, the myocardium contractile function during acute ischemic perturbations is not fully explored. A fully… read more here.
Keywords: cardiac electromechanical; model; ischemic conditions; contractile function ... See more keywords
NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10040762
Abstract: Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a mainstay of acute ischemic stroke treatment but is associated with bleeding complications, especially after prolonged large vessel occlusion. Recently, inhibition of the NLRP3 inflammasome led to… read more here.
Keywords: bbb; inhibition; inhibition reduces; nlrp3 inhibition ... See more keywords