Injectable Glucose‐Releasing Microgels Enhance the Survival and Therapeutic Potential of Transplanted MSCs Under Ischemic Conditions
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DOI: 10.1002/adhm.202401724
Abstract: Mesenchymal stem cell (MSC)‐based therapies show potential to treat ischemic diseases owing to their versatile functions. However, sustaining MSC viability and therapeutic efficacy in ischemic tissues postengraftment remains a significant challenge. This is because, although… read more here.
Keywords: glucose releasing; ischemic conditions; injectable glucose; therapeutic potential ... See more keywords
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions
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DOI: 10.1007/s10522-019-09805-6
Abstract: Nicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a… read more here.
Keywords: adenine dinucleotide; emerges therapeutic; ischemic conditions; nicotinamide adenine ... See more keywords
Cardiac Electromechanical Coupling Model of Myocardial Contractile Function under Ischemic Conditions
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DOI: 10.1016/j.bpj.2016.11.578
Abstract: Hyperkalemia, acidosis, and anoxia are major pathophysiological conditions of myocardial ischemia. Cardiac arrhythmias induced by these conditions are widely investigated. However, the myocardium contractile function during acute ischemic perturbations is not fully explored. A fully… read more here.
Keywords: cardiac electromechanical; model; ischemic conditions; contractile function ... See more keywords
NLRP3 Inhibition Reduces rt-PA Induced Endothelial Dysfunction under Ischemic Conditions
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DOI: 10.3390/biomedicines10040762
Abstract: Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is a mainstay of acute ischemic stroke treatment but is associated with bleeding complications, especially after prolonged large vessel occlusion. Recently, inhibition of the NLRP3 inflammasome led to… read more here.
Keywords: bbb; inhibition; inhibition reduces; nlrp3 inhibition ... See more keywords
Clopidogrel Influences Fracture Healing Under Ischemic Conditions
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DOI: 10.3390/biomedicines13092286
Abstract: Background/Objectives: Patients suffering from fractures are often treated with clopidogrel during the phase of bone healing due to multiple comorbidities. Studies indicate that clopidogrel suppresses osteoblast proliferation and the formation of trabecular bone. However, it… read more here.
Keywords: ischemic conditions; healing ischemic; fracture healing; bone ... See more keywords
Prospects of Intravenous Coenzyme Q10 Administration in Emergency Ischemic Conditions
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DOI: 10.3390/life14010134
Abstract: Coenzyme CoQ10 (CoQ10) is an endogenous lipid-soluble antioxidant that effectively protects lipids, proteins, and DNA from oxidation due to its ability to undergo redox transitions between oxidized and reduced forms. Various oxidative stress-associated infectious and… read more here.
Keywords: administration emergency; ischemic conditions; prospects intravenous; administration ... See more keywords