Transplantation of Cardiac Mesenchymal Stem Cell-Derived Exosomes Promotes Repair in Ischemic Myocardium
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-018-9822-0
Abstract: Our previous study demonstrated the beneficial effects of exosomes secreted by cardiac mesenchymal stem cells (C-MSC-Exo) in protecting acute ischemic myocardium from reperfusion injury. Here, we investigated the effect of exosomes from C-MSC on angiogenesis… read more here.
Keywords: msc exo; mesenchymal stem; ischemic myocardium; cardiac mesenchymal ... See more keywords
PEDF increases GLUT4-mediated glucose uptake in rat ischemic myocardium via PI3K/AKT pathway in a PEDFR-dependent manner.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2019.02.035
Abstract: BACKGROUND Targeted increase in glucose uptake of ischemic myocardium is a potential therapeutic strategy for myocardial ischemia. PEDF presents a profound moderating effect on glucose metabolism of cells, but its role is still controversial. Here,… read more here.
Keywords: uptake ischemic; pedf; glucose uptake; ischemic myocardium ... See more keywords
A "Hibernating-Like" Viable State Induced by Lentiviral Vector-Mediated Pigment Epithelium-Derived Factor Overexpression in Rat Acute Ischemic Myocardium.
Sign Up to like & getrecommendations! Published in 2019 at "Human gene therapy"
DOI: 10.1089/hum.2018.186
Abstract: The failure to maintain the viability of ischemic myocardium is one of the mechanisms that causes ischemic heart dysfunction after revascularization. Hibernating myocardium is considered to be able to maintain long-term viability during chronic hypoperfusion.… read more here.
Keywords: overexpression; pedf; myocardium; acute ischemic ... See more keywords
A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Nanobiotechnology"
DOI: 10.1186/s12951-021-00822-7
Abstract: Background Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the… read more here.
Keywords: imaging ischemic; invasive nanoparticles; myocardium; multimodal imaging ... See more keywords
Comparative Analysis of Normoxia- and Hypoxia-Modified Extracellular Vesicle Therapy in Function, Perfusion, and Collateralization in Chronically Ischemic Myocardium
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032076
Abstract: We have previously shown that normoxia serum-starved extracellular vesicle (EV) therapy improves myocardial function, perfusion, and angiogenesis in a swine model of chronic myocardial ischemia. Hypoxia-modified EVs have increased abundance of anti-oxidant, pro-angiogenic, and pro-survival… read more here.
Keywords: hypoxia; hypoxia modified; ischemic myocardium; function perfusion ... See more keywords
MMP 9-instructed assembly of bFGF nanofibers in ischemic myocardium to promote heart repair
Sign Up to like & getrecommendations! Published in 2022 at "Theranostics"
DOI: 10.7150/thno.77345
Abstract: Background: The only effective treatment for myocardial infarction (MI) is the timely restoration of coronary blood flow in the infarcted area, but further reperfusion exacerbates myocardial injury and leads to distal coronary no-reflow, which affects… read more here.
Keywords: bfgf micelle; mmp instructed; myocardium; ischemic myocardium ... See more keywords