Four Decades of Ischemic Penumbra and Its Implication for Ischemic Stroke.
Sign Up to like & getrecommendations! Published in 2021 at "Translational stroke research"
DOI: 10.1007/s12975-021-00916-2
Abstract: The ischemic penumbra defined four decades ago has been the main battleground of ischemic stroke. The evolving ischemic penumbra concept has been providing insight for the development of vascular and cellular approaches as well as… read more here.
Keywords: four decades; ischemic penumbra; ischemic stroke; implication ... See more keywords
Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/abe68a
Abstract: Objective. In ischemic stroke, treatments to protect neurons from irreversible damage are urgently needed. Studies in animal models have shown that neuroprotective treatments targeting neuronal silencing improve brain recovery, but in clinical trials none of… read more here.
Keywords: ischemic penumbra; hypoxic preconditioning; model ischemic; human neuronal ... See more keywords
Use of susceptibility-weighted imaging in assessing ischemic penumbra
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006091
Abstract: Rationale: The ischemic penumbra assessment is essential for the subsequent therapy and prediction of evolution in patients with acute ischemic infraction. Although controversial as a perfect equivalence to penumbra, perfusion-weighted imaging (PWI)-diffusion-weighted imaging (DWI) mismatch… read more here.
Keywords: susceptibility weighted; weighted imaging; swi; penumbra ... See more keywords
Plasma mid‐regional pro‐adrenomedullin: A biomarker of the ischemic penumbra in hyperacute stroke
Sign Up to like & getrecommendations! Published in 2022 at "Brain Pathology"
DOI: 10.1111/bpa.13110
Abstract: Reperfusion therapy has improved the outcomes of ischemic stroke but also emphasized the importance of ischemic penumbra. However, blood biomarkers are currently unavailable for this region. Adrenomedullin (ADM) is a neuroprotective peptide, secreted in a… read more here.
Keywords: biomarker; proadm; ischemic penumbra; mid regional ... See more keywords
Differentiation of the Infarct Core from Ischemic Penumbra within the First 4.5 Hours, Using Diffusion Tensor Imaging-Derived Metrics: A Rat Model
Sign Up to like & getrecommendations! Published in 2017 at "Korean Journal of Radiology"
DOI: 10.3348/kjr.2017.18.2.269
Abstract: Objective To investigate whether the diffusion tensor imaging-derived metrics are capable of differentiating the ischemic penumbra (IP) from the infarct core (IC), and determining stroke onset within the first 4.5 hours. Materials and Methods All… read more here.
Keywords: imaging derived; diffusion; derived metrics; tensor imaging ... See more keywords
Clinical Imaging of the Penumbra in Ischemic Stroke: From the Concept to the Era of Mechanical Thrombectomy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.861913
Abstract: The ischemic penumbra is defined as the severely hypoperfused, functionally impaired, at-risk but not yet infarcted tissue that will be progressively recruited into the infarct core. Early reperfusion aims to save the ischemic penumbra by… read more here.
Keywords: mechanical thrombectomy; ischemic stroke; ischemic penumbra; penumbra ... See more keywords
Penumbra Detection With Oxygen Extraction Fraction Using Magnetic Susceptibility in Patients With Acute Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2022.752450
Abstract: Background The oxygen extraction fraction (OEF) has been applied to identify ischemic penumbral tissue, but is difficult to use in an urgent care setting. This study aimed to investigate whether an OEF map generated via… read more here.
Keywords: ischemic penumbra; susceptibility; acute ischemic; penumbra ... See more keywords
Pretreatment with simvastatin upregulates expression of BK-2R and CD11b in the ischemic penumbra of rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomedical Research"
DOI: 10.7555/jbr.32.20160152
Abstract: Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductases, collectively known as statins, have been shown to minimize cerebral ischemic events in patients. We assessed the mechanisms of simvastatin pretreatment in preventing cerebral ischemia/reperfusion injury in rats using… read more here.
Keywords: cd11b ischemic; ischemic penumbra; expression cd11b; penumbra ... See more keywords