Evidence for an involvement of the ubiquitin‐like modifier ISG15 in MHC class I antigen presentation
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Immunology"
DOI: 10.1002/eji.202048646
Abstract: The IFN stimulated gene 15 (ISG15) encodes a 15‐kDa ubiquitin‐like protein, that is induced by type I IFNs and is conjugated to the bulk of newly synthesized polypeptides at the ribosome. ISG15 functions as an… read more here.
Keywords: presentation; ubiquitin like; isg15; antigen presentation ... See more keywords
Role of ISG15 post-translational modification in immunity against Mycobacterium tuberculosis infection.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110329
Abstract: ISG15 encoded by a type I interferon (IFN) inducible gene mediates an important cellular process called ISGylation. ISGylation emerges as a powerful host tactic against intracellular pathogens like Mycobacterium tuberculosis (Mtb). However, the exact role… read more here.
Keywords: mycobacterium tuberculosis; immunity; isgylation; isg15 ... See more keywords
ISG15 is downregulated by KLF12 and implicated in maintenance of cancer stem cell‐like features in cisplatin‐resistant ovarian cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16503
Abstract: Drug resistance is often developed during clinical chemotherapy of ovarian cancers. The ubiquitin‐like protein interferon‐stimulated gene 15 (ISG15) is possibly dependent on tumour context to promote or suppress progression of various tumours. The ubiquitin‐like protein… read more here.
Keywords: resistant ovarian; cisplatin resistant; isg15; ovarian cancer ... See more keywords
Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00462-18
Abstract: Proteins can be conjugated covalently by ubiquitin or ubiquitin-like proteins, such as SUMO and ISG15. ISG15 is highly induced in viral infection, and ISG15 conjugation, termed ISGylation, plays important regulatory roles in viral growth. Although… read more here.
Keywords: protein; pul50; isg15; isgylation ... See more keywords
Free ISG15 Inhibits the Replication of Peste des Petits Ruminants Virus by Breaking the Interaction of Nucleoprotein and Phosphoprotein
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01031-22
Abstract: PPRV, a widespread and fatal disease of small ruminants, is one of the most devastating animal diseases in Africa, the Middle East, and Asia, causing severe economic losses. IFNs play an important role as a… read more here.
Keywords: free isg15; isg15 inhibits; role; pprv infection ... See more keywords
Abstract LB156: Identified the ISG15 mediated extracellular vesicles drives ovarian cancer progression and metastasis: extracellular vesicular ISG15 is a potential biomarker and therapeutic target
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb156
Abstract: Background & Objective: High-grade serous ovarian cancer (HGSOC) accounts for over 80% of all epithelial ovarian cancer (OC) diagnoses, and the majority of patients with HGSOC are diagnosed with advanced metastatic disease. Aberrant expression of… read more here.
Keywords: progression metastasis; cancer; ovarian cancer; isg15 ... See more keywords
UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15182
Abstract: Esophageal cancer remains a poor prognosis cancer due to advanced stage of presentation and drug resistant disease. To understand the molecular mechanisms influencing response to chemotherapy, we examined genes that are differentially expressed between drug… read more here.
Keywords: esophageal cancer; isg15; drug; cancer cells ... See more keywords
Comparison of ISG15, IL28B and USP18 mRNA levels in peripheral blood mononuclear cells of chronic hepatitis B virus infected patients and healthy individuals
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology and Hepatology From Bed to Bench"
DOI: 10.22037/ghfbb.v0i0.1360
Abstract: Aim: The purpose of this study was to evaluate the expression level of Interferon-stimulated Gene 15 (ISG15), Interleukin28B (IL28B) or IFN-lambda-3 and Ubiquitin specific peptidase 18 (USP18) genes in Peripheral Blood Mononuclear Cells (PBMCs) of… read more here.
Keywords: expression; healthy individuals; gastroenterology; il28b ... See more keywords
The proportion of C1q-high and ISG15-high monocytes in the skin of patients with Behçet disease
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1110741
Abstract: Behçet disease (BD) is a chronic systemic vasculitis that is clinically characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin lesions. Here, we conducted bulk RNA-seq of skin samples from 4 BD patients and… read more here.
Keywords: beh disease; proportion; skin patients; proportion c1q ... See more keywords
Targeting Ubiquitin-like Protein, ISG15, as a Novel Tumor Associated Antigen in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041237
Abstract: Simple Summary Despite their potential and promising anti-tumor efficacy, previously developed cancer vaccines targeting different tumor-associated antigens for colorectal cancer (CRC) have not yet proven to be successful. Interferon-stimulated gene 15 (ISG15) is emerging as… read more here.
Keywords: isg15; crc; colorectal cancer; tumor ... See more keywords
ISG15, a Small Molecule with Huge Implications: Regulation of Mitochondrial Homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Viruses"
DOI: 10.3390/v10110629
Abstract: Viruses are responsible for the majority of infectious diseases, from the common cold to HIV/AIDS or hemorrhagic fevers, the latter with devastating effects on the human population. Accordingly, the development of efficient antiviral therapies is… read more here.
Keywords: regulation mitochondrial; isg15 small; isg15; small molecule ... See more keywords