A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52870-w
Abstract: Usutu virus (USUV) and West Nile virus (WNV) are two closely related emerging mosquito-borne flaviviruses. Their natural hosts are wild birds, but they can also cause severe neurological disorders in humans. Both viruses are efficiently… read more here.
Keywords: exonuclease; isg20; untranslated region; usutu virus ... See more keywords
ISG20 promotes local tumor immunity and contributes to poor survival in human glioma
Sign Up to like & getrecommendations! Published in 2019 at "Oncoimmunology"
DOI: 10.1080/2162402x.2018.1534038
Abstract: ABSTRACT Recent evidence has confirmed that a mutation of the isocitrate dehydrogenase (IDH) gene occurs early in gliomagenesis and contributes to suppressed immunity. The present study aimed to determine the candidate genes associated with IDH… read more here.
Keywords: expression; immunity; glioma; isg20 ... See more keywords
Interferon-stimulated gene 20 (ISG20) selectively degrades N6-methyladenosine modified Hepatitis B Virus transcripts
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1008338
Abstract: Interferon (IFN) stimulates a whole repertoire of cellular genes, collectively referred to as ISGs (Interferon-stimulated genes). ISG20, a 3´-5´ exonuclease enzyme, has been previously shown to bind and degrade hepatitis B Virus (HBV) transcripts. Here,… read more here.
Keywords: hbv transcripts; rna; m6a modified; hepatitis virus ... See more keywords