Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA‐induced differentiation of leukemic cells
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12614
Abstract: Ubiquitin/ISG15‐conjugating enzyme E2L6 (UBE2L6) is a critical enzyme in ISGylation, a post‐translational protein modification that conjugates the ubiquitin‐like modifier, interferon‐stimulated gene 15 (ISG15), to target substrates. Previous gene expression studies in acute promyelocytic leukemia (APL)… read more here.
Keywords: atra induced; isgylation; apl cells; expression ... See more keywords
Interplay between interferon-stimulated gene 15/ISGylation and interferon gamma signaling in breast cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.11.021
Abstract: Interferon-stimulated gene 15 (ISG15) is a ubiquitin-like protein that conjugates to its target proteins to modify them through ISGylation, but the relevance of ISG15 expression and its effects have been not completely defined. Herein, we… read more here.
Keywords: interferon stimulated; isgylation; breast cancer;
Role of ISG15 post-translational modification in immunity against Mycobacterium tuberculosis infection.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110329
Abstract: ISG15 encoded by a type I interferon (IFN) inducible gene mediates an important cellular process called ISGylation. ISGylation emerges as a powerful host tactic against intracellular pathogens like Mycobacterium tuberculosis (Mtb). However, the exact role… read more here.
Keywords: mycobacterium tuberculosis; immunity; isgylation; isg15 ... See more keywords
ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02017-8
Abstract: ISG15 is an ubiquitin-like modifier that is associated with reduced survival rates in breast cancer patients. The mechanism by which ISG15 achieves this however remains elusive. We demonstrate that modification of Rab GDP-Dissociation Inhibitor Beta… read more here.
Keywords: basal breast; isgylation; egfr recycling; tumour progression ... See more keywords
miR‐2909 regulates ISGylation system via STAT1 signalling through negative regulation of SOCS3 in prostate cancer
Sign Up to like & getrecommendations! Published in 2017 at "Andrology"
DOI: 10.1111/andr.12374
Abstract: One of the well‐document strategies adopted by tumour cells for progression is to evade immune surveillance mechanisms. An understanding of the tight interaction between immunity and progression of cancer can provide novel treatment options for… read more here.
Keywords: prostate; isgylation; mir 2909; cancer ... See more keywords
Protein modification with ISG15 blocks coxsackievirus pathology by antiviral and metabolic reprogramming
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aay1109
Abstract: Protein modification with ISG15 acts cooperatively with IFIT proteins and preserves glucose homeostasis. Protein modification with ISG15 (ISGylation) represents a major type I IFN–induced antimicrobial system. Common mechanisms of action and species-specific aspects of ISGylation,… read more here.
Keywords: modification isg15; protein modification; isgylation; pathology ... See more keywords
Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00462-18
Abstract: Proteins can be conjugated covalently by ubiquitin or ubiquitin-like proteins, such as SUMO and ISG15. ISG15 is highly induced in viral infection, and ISG15 conjugation, termed ISGylation, plays important regulatory roles in viral growth. Although… read more here.
Keywords: protein; pul50; isg15; isgylation ... See more keywords
Human Respiratory Syncytial Virus NS2 Protein Induces Autophagy by Modulating Beclin1 Protein Stabilization and ISGylation
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03528-21
Abstract: Understanding host-virus interactions is essential for the development of effective interventions against respiratory syncytial virus (RSV), a paramyxovirus that is a leading cause of viral pneumonia in infants. RSV induces autophagy following infection, although the… read more here.
Keywords: beclin1; rsv; respiratory syncytial; virus ... See more keywords
ISGylation of NF-κBp65 by SCFFBXL19 E3 Ligase Diminishes Endothelial Inflammation
Sign Up to like & getrecommendations! Published in 2023 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.122.318894
Abstract: Background: NF-κB (nuclear factor kappa B) plays a pivotal role in endothelial cell (EC) inflammation. Protein ISGylation is regulated by E3 ISG15 (interferon-stimulated gene 15) ligases; however, ISGylation of NF-κBp65 and its role in EC… read more here.
Keywords: inflammation; role; isgylation; p65 ... See more keywords
ISGylation is increased in the peripheral blood mononuclear cells derived from symptomatic COVID-19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Experimental Biology and Medicine"
DOI: 10.1177/15353702221075606
Abstract: Cytokine-driven hyper inflammation has been identified as a critical factor behind poor outcomes in patients severely infected with SARS-CoV-2 virus. Notably, protein ISGylation, a protein conjugated form of Type 1 IFN-inducible ubiquitin-like protein ISG15 (Interferon-Stimulated… read more here.
Keywords: inflammation; covid patients; isgylation; isgylation increased ... See more keywords
ISGylation – a key to lock the cell gates for preventing the spread of threats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.205468
Abstract: ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α and -β, ischemia, DNA damage and aging. Attention has historically focused on… read more here.
Keywords: lock cell; isgylation; exosome secretion; cell gates ... See more keywords