Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization
Sign Up to like & getrecommendations! Published in 2022 at "Drug Delivery"
DOI: 10.1080/10717544.2022.2096714
Abstract: Abstract Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential for corneal neovascularization (CNV) treatment; however, its therapeutic use is restricted due to its poor aqueous solubility and limited bioavailability. To… read more here.
Keywords: corneal neovascularization; isl; treatment; isoliquiritigenin ... See more keywords
Islatravir: evaluation of clinical development for HIV and HBV
Sign Up to like & getrecommendations! Published in 2024 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2024.2305130
Abstract: ABSTRACT Introduction Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) that inhibits HIV RT through multiple mechanisms. Contrary to all approved NtRTIs, islatravir retains a 3’OH group. In vitro and clinical data show… read more here.
Keywords: drug; isl; hiv hbv; development ... See more keywords
Efficacy and safety of doravirine/islatravir in heavily treatment-experienced participants living with HIV-1 from a randomized trial.
Sign Up to like & getrecommendations! Published in 2025 at "AIDS"
DOI: 10.1097/qad.0000000000004367
Abstract: Objective: This study evaluated the efficacy (day 8) and safety (week 49) of doravirine/islatravir (DOR/ISL; 100 mg/0.75 mg) plus baseline antiretroviral therapy (ART) and optimized background therapy (OBT) in heavily treatment-experienced (HTE) adults living with detectable HIV-1… read more here.
Keywords: week; hiv; efficacy; isl ... See more keywords
Chloroflexus islandicus sp. nov., a thermophilic filamentous anoxygenic phototrophic bacterium from a geyser.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of systematic and evolutionary microbiology"
DOI: 10.1099/ijsem.0.001820
Abstract: A novel, thermophilic filamentous anoxygenic phototrophic bacterium, strain isl-2T, was isolated from the Strokkur Geyser, Iceland. Strain isl-2T formed unbranched multicellular filaments with gliding motility. The cells formed no spores and stained Gram-negative. The existence… read more here.
Keywords: isl; chloroflexus; thermophilic filamentous; filamentous anoxygenic ... See more keywords
The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pharmacology & Toxicology"
DOI: 10.1186/s40360-017-0165-2
Abstract: BackgroundIsoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute to the aberrant proliferation of vascular smooth muscle cells (VSMCs).… read more here.
Keywords: isl; pi3k akt; proliferation; smooth muscle ... See more keywords
Long-Circulation and Brain Targeted Isoliquiritigenin Micelle Nanoparticles: Formation, Characterization, Tissue Distribution, Pharmacokinetics and Effects for Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s368528
Abstract: Purpose We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-PEG2000 as the drug carrier modified with the brain-targeting polypeptide angiopep-2 to improve the poor water solubility and low bioavailability of ISL for the… read more here.
Keywords: brain targeted; isl; brain; drug ... See more keywords
Long-Circulating and Brain-Targeted Liposomes Loaded with Isoliquiritigenin: Formation, Characterization, Pharmacokinetics, and Distribution
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics16080975
Abstract: Isoliquiritigenin (ISL) has excellent neuroprotective effects. However, its limitations, including poor solubility, low bioavailability, and low accumulation in the brain, restrict its clinical promotion. In this study, a novel type of ISL-loaded liposome (ISL-LP) modified… read more here.
Keywords: circulating brain; brain targeted; distribution; brain ... See more keywords