Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization
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DOI: 10.1080/10717544.2022.2096714
Abstract: Abstract Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential for corneal neovascularization (CNV) treatment; however, its therapeutic use is restricted due to its poor aqueous solubility and limited bioavailability. To… read more here.
Keywords: corneal neovascularization; isl; treatment; isoliquiritigenin ... See more keywords
Chloroflexus islandicus sp. nov., a thermophilic filamentous anoxygenic phototrophic bacterium from a geyser.
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DOI: 10.1099/ijsem.0.001820
Abstract: A novel, thermophilic filamentous anoxygenic phototrophic bacterium, strain isl-2T, was isolated from the Strokkur Geyser, Iceland. Strain isl-2T formed unbranched multicellular filaments with gliding motility. The cells formed no spores and stained Gram-negative. The existence… read more here.
Keywords: isl; chloroflexus; thermophilic filamentous; filamentous anoxygenic ... See more keywords
The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell
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DOI: 10.1186/s40360-017-0165-2
Abstract: BackgroundIsoliquiritigenin (ISL) has various biological activities including as antioxidant and an inhibitor of PI3K/AKT signaling pathway. However, both oxidative stress and activated PI3K/AKT signaling contribute to the aberrant proliferation of vascular smooth muscle cells (VSMCs).… read more here.
Keywords: isl; pi3k akt; proliferation; smooth muscle ... See more keywords
Long-Circulation and Brain Targeted Isoliquiritigenin Micelle Nanoparticles: Formation, Characterization, Tissue Distribution, Pharmacokinetics and Effects for Ischemic Stroke
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DOI: 10.2147/ijn.s368528
Abstract: Purpose We designed a novel isoliquiritigenin (ISL) loaded micelle prepared with DSPE-PEG2000 as the drug carrier modified with the brain-targeting polypeptide angiopep-2 to improve the poor water solubility and low bioavailability of ISL for the… read more here.
Keywords: brain targeted; isl; brain; drug ... See more keywords