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   Articles with "isl1" as a keyword



ISL1 is a major susceptibility gene for classic bladder exstrophy and a regulator of urinary tract development

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep42170

Abstract: Previously genome-wide association methods in patients with classic bladder exstrophy (CBE) found association with ISL1, a master control gene expressed in pericloacal mesenchyme. This study sought to further explore the genetics in a larger set… read more here.

Keywords: urinary tract; isl1; gene; classic bladder ... See more keywords
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ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2207433119

Abstract: A cardinal feature of the auditory pathway is frequency selectivity, represented in a tonotopic map from the cochlea to the cortex. The molecular determinants of the auditory frequency map are unknown. Here, we discovered that… read more here.

Keywords: auditory pathway; auditory; cochlea; spiral ganglion ... See more keywords
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Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex.

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recommendations! Published in 2021 at "Cerebral cortex"

DOI: 10.1093/cercor/bhab152

Abstract: Cortical interneurons (GABAergic cells) arise during embryogenesis primarily from the medial and caudal ganglionic eminences (MGE and CGE, respectively) with a small population generated from the preoptic area (POA). Progenitors from the lateral ganglionic eminence… read more here.

Keywords: islet1 precursors; isl1; precursors contribute; population ... See more keywords
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Isl1 promotes gene transcription through physical interaction with Set1/Mll complexes.

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recommendations! Published in 2023 at "European journal of cell biology"

DOI: 10.2139/ssrn.4157445

Abstract: Histone H3 lysine 4 (H3K4) methylation is generally recognized as a prominent marker of gene activation. While Set1/Mll complexes are major methyltransferases that are responsible for H3K4 methylation, the mechanism of how these complexes are… read more here.

Keywords: gene; mll complexes; set1 mll; isl1 ... See more keywords

Collaborative ISL1/GATA3 interaction in controlling neuroblastoma oncogenic pathways overlapping with but distinct from MYCN

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recommendations! Published in 2019 at "Theranostics"

DOI: 10.7150/thno.30199

Abstract: Background: Transcription factor ISL1 plays a critical role in sympathetic neurogenesis. Expression of ISL1 has been associated with neuroblastoma, a pediatric tumor derived from sympatho-adrenal progenitors, however the role of ISL1 in neuroblastoma remains unexplored.… read more here.

Keywords: isl1 gata3; isl1; mycn; neuroblastoma ... See more keywords