Statin downregulation of miR-652-3p protects endothelium from dyslipidemia by promoting ISL1 expression.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154226
Abstract: BACKGROUND Aberrant endothelial function is a major contributing factor in cardiovascular disease. Dyslipidemia leads to decreased nitric oxide (NO) bioavailability, an early sign of endothelial failure. Low insulin gene enhancer protein (ISL1) levels decrease healthy… read more here.
Keywords: isl1 protein; isl1 expression; dyslipidemia; mir 652 ... See more keywords
Role of miR-128/216a Regulating Isl1 Expression during Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Insulin-Producing Cells
Sign Up to like & getrecommendations! Published in 2023 at "Wuhan University Journal of Natural Sciences"
DOI: 10.1051/wujns/2023282177
Abstract: Islet-1 (Isl1), a LIM homeodomain protein, is expressed in the embryonic pancreatic epithelium. As a key transcription factor, Isl1 can not only regulate insulin gene expression in normal glucose condition but also maintain β-cell function… read more here.
Keywords: isl1 expression; expression; insulin producing; differentiation ... See more keywords