CpG Island Methylator Phenotype May Predict Poor Overall Survival of Patients with Stage IV Colorectal Cancer
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DOI: 10.1159/000493387
Abstract: Objective: We aimed to study the prognostic role of CpG island methylator phenotype (CIMP) in patients with different stages of colorectal cancer (CRC). Material and Methods: We analyzed CIMP in stage I–IV CRC specimens from… read more here.
Keywords: cimp; cpg island; island methylator; crc ... See more keywords
The CpG island methylator phenotype is concordant between primary colorectal carcinoma and matched distant metastases
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Epigenetics"
DOI: 10.1186/s13148-017-0347-1
Abstract: BackgroundThe CpG island methylator phenotype (CIMP) in stage III colon cancer (CRC) has been associated with improved survival after treatment with adjuvant irinotecan-based chemotherapy. In this analysis, we determine whether CIMP status in the primary… read more here.
Keywords: status; cimp; island methylator; cpg island ... See more keywords
Potent predictive CpG signature for temozolomide response in non-glioma-CpG island methylator phenotype glioblastomas with methylated MGMT promoter.
Sign Up to like & getrecommendations! Published in 2022 at "Epigenomics"
DOI: 10.2217/epi-2022-0344
Abstract: Aim: We aimed to identify potent CpG signatures predicting temozolomide (TMZ) response in glioblastomas (GBMs) that do not have the glioma-CpG island methylator phenotype (G-CIMP) but have a methylated promoter of MGMT (meMGMT). Materials &… read more here.
Keywords: cpg island; methylator phenotype; glioma cpg; response ... See more keywords
Advances in CpG Island Methylator Phenotype Colorectal Cancer Therapies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.629390
Abstract: With the aging of the population, the incidence of colorectal cancer in China is increasing. One of the epigenetic alterations: CpG island methylator phenotype (CIMP) plays an important role in the incidence of colorectal cancer.… read more here.
Keywords: colorectal cancer; island methylator; cpg island; methylator phenotype ... See more keywords
CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere?
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DOI: 10.3390/ijms23020830
Abstract: The CpG island methylator phenotype (CIMP) can be regarded as the most notable emanation of epigenetic instability in cancer. Since its discovery in the late 1990s, CIMP has been extensively studied, mainly in colorectal cancers… read more here.
Keywords: methylator phenotype; solid tumours; island methylator; cpg island ... See more keywords