Pharmacokinetics of Atorvastatin and Metformin after Coadministration with Islatravir in Healthy Adults
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.6169
Abstract: Islatravir, a deoxyadenosine analog that inhibits HIV‐1 replication by multiple mechanisms of action, including reverse transcriptase translocation inhibition, is being developed for use in HIV‐1 treatment. People living with HIV often have comorbidities, such as… read more here.
Keywords: islatravir; coadministration; atorvastatin; healthy adults ... See more keywords
Kinetic Insights into the Enhanced Antiviral Activity of Islatravir against Doravirine Resistance-Associated Substitution Mutations in HIV-1 Reverse Transcriptase.
Sign Up to like & getrecommendations! Published in 2025 at "Biochemistry"
DOI: 10.1021/acs.biochem.5c00397
Abstract: Islatravir (ISL, EFdA) is a nucleoside analog that inhibits HIV-1 reverse transcriptase (RT) translocation during viral replication. Its high potency stems from unique structural features: a 4'-ethynyl group that interacts with the hydrophobic pocket (containing… read more here.
Keywords: resistance; islatravir; doravirine; hiv reverse ... See more keywords
Intracellular islatravir-triphosphate half-life supports extended dosing intervals
Sign Up to like & getrecommendations! Published in 2024 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00458-24
Abstract: ABSTRACT Antiretroviral therapy has substantially reduced morbidity, mortality, and disease transmission in people living with HIV. Islatravir is a nucleoside reverse transcriptase translocation inhibitor that inhibits HIV-1 replication by multiple mechanisms of action, and it… read more here.
Keywords: islatravir triphosphate; extended dosing; half life; islatravir ... See more keywords
Thorough QT/QTc study to evaluate the effect of a single supratherapeutic dose of islatravir on QTc interval prolongation in healthy adults
Sign Up to like & getrecommendations! Published in 2024 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00464-24
Abstract: ABSTRACT Islatravir is a deoxynucleoside analog being developed for the treatment of HIV-1 infection. Clinical studies are being conducted to evaluate islatravir, administered in combination with other antiretroviral therapies, at doses of 0.25 mg once… read more here.
Keywords: evaluate effect; islatravir; qtc; supratherapeutic dose ... See more keywords