Islet Transplantation: Growing Trans‐Species Islets in Tumor Extract‐Remodeled Testicles (Adv. Sci. 6/2019)
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DOI: 10.1002/advs.201970036
Abstract: In article number 1801694, Junfeng Zhang, Chunming Wang, Lei Dong, and co‐workers biochemically remodel one of the two testicles of a mouse into a site that can protect xenogeneic islet cells from immune rejection. The… read more here.
Keywords: growing trans; islet; trans species; transplantation growing ... See more keywords
Tissue‐engineering approaches in pancreatic islet transplantation
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DOI: 10.1002/bit.26821
Abstract: Pancreatic islet transplantation is a promising alternative to whole‐pancreas transplantation as a treatment of type 1 diabetes mellitus. This technique has been extensively developed during the past few years, with the main purpose of minimizing… read more here.
Keywords: pancreatic islet; islet; islet transplantation; transplantation ... See more keywords
Non autoimmune type 1B diabetes after mild COVID‐19: Report of three cases
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DOI: 10.1002/dmrr.3438
Abstract: To the Editor, We read with interest the recent commentary published in the journal wherein Maddaloni and Buzzetti describe the potential increase in the risk of new onset diabetes secondary to coronavirus disease 2019 (COVID‐19)… read more here.
Keywords: insulin; islet; infection; type diabetes ... See more keywords
Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets.
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DOI: 10.1002/jbio.202000375
Abstract: Pancreatic islet isolation from donor pancreases is an essential step for the transplantation of insulin-secreting β-cells as a therapy to treat type 1 diabetes mellitus. This process however damages islet basement membranes, which can lead… read more here.
Keywords: islet; pseudo islets; transplantation; lifetime metabolic ... See more keywords
MicroRNA‐30d preserves pancreatic islet β‐cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin‐induced diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26569
Abstract: The loss of pancreatic islet β‐cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet… read more here.
Keywords: streptozotocin induced; jnk; islet; mir 30d ... See more keywords
A silk‐based encapsulation platform for pancreatic islet transplantation improves islet function in vivo
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DOI: 10.1002/term.1990
Abstract: The success of pancreatic islet (PI) transplantation is challenged by PI functional damage during the peritransplantation period. A silk‐based encapsulation platform including mesenchymal stromal cells (MSCs) was evaluated for islet cell delivery in vivo. Islet… read more here.
Keywords: pancreatic islet; islet; silk; islet transplantation ... See more keywords
The potential role of multifunctional human amniotic epithelial cells in pancreatic islet transplantation
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DOI: 10.1002/term.3214
Abstract: Pancreatic islet cell transplantation has proven efficacy as a treatment for type 1 diabetes mellitus, chiefly in individuals who are refractory to conventional insulin replacement therapy. At present its clinical use is restricted, firstly by… read more here.
Keywords: pancreatic islet; epithelial cells; amniotic epithelial; islet ... See more keywords
Bioengineered human pseudoislets form efficiently from donated tissue, compare favourably with native islets in vitro and restore normoglycaemia in mice
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DOI: 10.1007/s00125-018-4672-5
Abstract: Aims/hypothesisIslet transplantation is a treatment option that can help individuals with type 1 diabetes become insulin independent, but inefficient oxygen and nutrient delivery can hamper islet survival and engraftment due to the size of the… read more here.
Keywords: favourably native; islet; compare favourably; mice ... See more keywords
Expression of immunoreactive inducible nitric oxide synthase in pancreatic islet cells from newly diagnosed and long-term type 1 diabetic donors is heterogeneous and not disease-associated.
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DOI: 10.1007/s00441-020-03340-4
Abstract: Exposure of isolated human islets to proinflammatory cytokines leads to up-regulation of inducible nitric oxide synthase (iNOS), raised NO, and beta cell toxicity. These findings have led to increasing interest in the clinical utility of… read more here.
Keywords: islet; group; disease; beta ... See more keywords
1,5-Anhydroglucitol × glycated hemoglobin A1c/100 as a potential biomarker for islet β-cell function among patients with type 2 diabetes
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DOI: 10.1007/s00592-019-01452-0
Abstract: This study aimed to explore the level of and changes in the 1,5-anhydroglucitol × glycated hemoglobin A1c/100 (AH index, AHI) associated with different glucose metabolism statuses and to evaluate the islet function and insulin sensitivity of patients… read more here.
Keywords: insulin; islet; anhydroglucitol glycated; hemoglobin a1c ... See more keywords
Successful allogeneic islet transplantation after total pancreatectomy with islet autotransplantation to restore normoglycemia: a case report
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01457-9
Abstract: Total pancreatectomy with islet autotransplantation (TPIAT) has been recognized as a treatment option for patients with refractory chronic pancreatitis (CP) who experience debilitating pain and impaired quality of life [1]. Restoring as much endocrine function… read more here.
Keywords: total pancreatectomy; islet; pancreatectomy islet; case ... See more keywords