Notch-mediated Ephrin signaling disrupts islet architecture and β cell function.
Sign Up to like & getrecommendations! Published in 2022 at "JCI insight"
DOI: 10.1172/jci.insight.157694
Abstract: Altered islet architecture is associated with β cell dysfunction and Type 2 Diabetes (T2D) progression, but molecular effectors of islet spatial organization remain mostly unknown. Although Notch signaling is known to regulate pancreatic development, we… read more here.
Keywords: ephrin signaling; cell; islet architecture; notch ... See more keywords
109-OR: Notch Signaling Controls Islet Architecture and ß-Cell Function in the Developed Pancreas
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-109-or
Abstract: Although β cell dysfunction is a well-appreciated contributor to type 2 diabetes (T2D) pathophysiology, determinants of β cell function are incompletely understood. For instance, disrupted islet architecture is associated with T2D progression in humans and… read more here.
Keywords: cell function; islet architecture; cell; notch ... See more keywords