Circulating metabolites in progression to islet autoimmunity and type 1 diabetes
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DOI: 10.1007/s00125-019-04980-0
Abstract: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type… read more here.
Keywords: control group; islet autoimmunity; type diabetes; type ... See more keywords
Tolerogenic Nanoparticles to Treat Islet Autoimmunity
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DOI: 10.1007/s11892-017-0914-z
Abstract: Purpose of ReviewThe current standard therapy for type 1 diabetes (T1D) is insulin replacement. Autoimmune diseases are typically treated with broad immunosuppression, but this has multiple disadvantages. Induction of antigen-specific tolerance is preferable. The application… read more here.
Keywords: islet autoimmunity; nanoparticles treat; tolerogenic nanoparticles; tolerance ... See more keywords
Dietary factors and risk of islet autoimmunity and type 1 diabetes: a systematic review and meta-analysis
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DOI: 10.1016/j.ebiom.2021.103633
Abstract: Background Numerous dietary components have been linked to the development of islet autoimmunity (IA) and type 1 diabetes (T1D); however, no associations are firmly established. This systematic review and meta-analysis aimed to synthesize current knowledge… read more here.
Keywords: islet autoimmunity; review meta; systematic review; type diabetes ... See more keywords
Vaccinations in early life are not associated with development of islet autoimmunity in type 1 diabetes high-risk children: Results from prospective cohort data.
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DOI: 10.1016/j.vaccine.2017.02.049
Abstract: AIMS/HYPOTHESIS Vaccinations in early childhood potentially stimulate the immune system and may thus be relevant for the pathogenesis of autoimmune diseases such as type 1 diabetes (T1D). We determined the association of vaccination burden with… read more here.
Keywords: risk; islet autoimmunity; cohort; autoimmunity ... See more keywords
Consumption of differently processed milk products in infancy and early childhood and the risk of islet autoimmunity
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DOI: 10.1017/s0007114520000744
Abstract: Abstract Several prospective studies have shown an association between cows’ milk consumption and the risk of islet autoimmunity and/or type 1 diabetes. We wanted to study whether processing of milk plays a role. A population-based… read more here.
Keywords: milk; consumption; risk; islet autoimmunity ... See more keywords
Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity – indications of immune cell activation
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DOI: 10.1038/s41598-019-42750-5
Abstract: Birth by Cesarean section increases the risk of developing type 1 diabetes later in life. We aimed to elucidate common regulatory processes observed after Cesarean section and the development of islet autoimmunity, which precedes type… read more here.
Keywords: cesarean section; gene; section; islet autoimmunity ... See more keywords
Protocol for a nested case-control study design for omics investigations in the Environmental Determinants of Islet Autoimmunity cohort
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DOI: 10.1080/07853890.2023.2198255
Abstract: Abstract Background: The Environmental Determinants of Islet Autoimmunity (ENDIA) pregnancy-birth cohort investigates the developmental origins of type 1 diabetes (T1D), with recruitment between 2013 and 2019. ENDIA is the first study in the world with… read more here.
Keywords: islet autoimmunity; control; study; nested case ... See more keywords
Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study
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DOI: 10.1136/jmedgenet-2018-105532
Abstract: Background Progression time from islet autoimmunity to clinical type 1 diabetes is highly variable and the extent that genetic factors contribute is unknown. Methods In 341 islet autoantibody-positive children with the human leucocyte antigen (HLA)… read more here.
Keywords: islet; progression; type diabetes; islet autoimmunity ... See more keywords
Islet Autoimmunity is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the Grade Study.
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DOI: 10.2139/ssrn.3810751
Abstract: Islet autoimmunity may contribute to β-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. In this ancillary study to the Glycemia Reduction Approaches in Diabetes-A Comparative Effectiveness… read more here.
Keywords: cell; islet autoimmunity; autoimmunity; cell function ... See more keywords
Islet Autoimmunity is Highly Prevalent and Associated With Diminished β-Cell Function in Patients With Type 2 Diabetes in the Grade Study.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-0590
Abstract: Islet autoimmunity may contribute to β-cell dysfunction in type 2 diabetes (T2D). Its prevalence and clinical significance have not been rigorously determined. In this ancillary study to the Glycemia Reduction Approaches in Diabetes-A Comparative Effectiveness… read more here.
Keywords: islet autoimmunity; cell function; cell; autoimmunity ... See more keywords
Changes in the Co-Expression of Innate Immunity Genes During Persistent Islet Autoimmunity are Associated with Progression of Islet Autoimmunity: The Diabetes Autoimmunity Study in the Young (DAISY).
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db21-1111
Abstract: Longitudinal changes in gene expression during islet autoimmunity (IA) may provide insight into biological processes that explain progression to type 1 diabetes (T1D). We identified individuals from DAISY who developed IA, autoantibodies present on two… read more here.
Keywords: gene; islet autoimmunity; autoimmunity; changes expression ... See more keywords