Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function
Sign Up to like & getrecommendations! Published in 2021 at "Diabetologia"
DOI: 10.1007/s00125-021-05389-4
Abstract: Failure of pancreatic and duodenal homeobox factor 1 (PDX1) to localise in the nucleus of islet beta cells under high-fat diet (HFD) conditions may be an early functional defect that contributes to beta cell failure… read more here.
Keywords: formation; beta; nucleocytoplasmic transport; beta cell ... See more keywords
Metabolic Adaptions/Reprogramming in Islet Beta-Cells in Response to Physiological Stimulators—What Are the Consequences
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DOI: 10.3390/antiox11010108
Abstract: Irreversible pancreatic β-cell damage may be a result of chronic exposure to supraphysiological glucose or lipid concentrations or chronic exposure to therapeutic anti-diabetic drugs. The β-cells are able to respond to blood glucose in a… read more here.
Keywords: cell; metabolic adaptions; adaptions reprogramming; reprogramming islet ... See more keywords