MicroRNA‐30d preserves pancreatic islet β‐cell function through negative regulation of the JNK signaling pathway via SOCS3 in mice with streptozotocin‐induced diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26569
Abstract: The loss of pancreatic islet β‐cell function represents the classical feature in the pathogenesis of type 2 diabetes mellitus (T2DM). Previous evidence has highlighted the involvement of the activated JNK pathway in relation to islet… read more here.
Keywords: streptozotocin induced; jnk; islet; mir 30d ... See more keywords
Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2017.07.013
Abstract: Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the… read more here.
Keywords: polymeric islet; advances polymeric; islet; cell encapsulation ... See more keywords
Generation of human islet cell type-specific identity genesets.
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DOI: 10.1038/s41467-022-29588-8
Abstract: Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity. Here, we conduct a… read more here.
Keywords: type specific; islet; cell type; islet cell ... See more keywords
The relationship between islet β-cell function and metabolomics in overweight patients with Type 2 diabetes
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DOI: 10.1042/bsr20221430
Abstract: Abstract A cross-sectional study was performed using metabolomics in overweight patients with Type 2 diabetes (T2D) at different stages of the disease. We aimed to identify potential metabolites for assessing islet β-cell function in order… read more here.
Keywords: islet cell; cell function; overweight patients;
Expanding indications for pancreatic islet cell transplantation.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Gastroenterology"
DOI: 10.1097/mog.0000000000000660
Abstract: PURPOSE OF REVIEW We aimed to summarize the current state of performing pancreatic islet autotransplantation (IAT) for indications other than total pancreatectomy for chronic pancreatitis. RECENT FINDINGS The current article will review expanded indications for… read more here.
Keywords: iat; islet; islet cell; pancreatic islet ... See more keywords
Pancreatic islet cell transplantation.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in organ transplantation"
DOI: 10.1097/mot.0000000000000458
Abstract: DOI:10.1097/MOT.0000000000000458 This edition of Current Opinion in Organ Transplantation briefly highlights a journey away from organs and toward cell-based therapy, namely the transplantation of the pancreatic islet. Three expert reviews bring the readership up-to-date on… read more here.
Keywords: islet; cell transplantation; transplantation; transplantation pancreatic ... See more keywords
Preferences for Risks and Benefits of Islet Cell Transplantation for Persons With Type 1 Diabetes With History of Episodes of Severe Hypoglycemia: A Discrete-Choice Experiment to Inform Regulatory Decisions
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DOI: 10.1097/tp.0000000000004189
Abstract: Background. The advisory panel for US Food and Drug Administration (FDA) recently endorsed pancreatic islet cell transplantation (ICT) therapy for suboptimally controlled type 1 diabetes (T1D), and FDA approval is under consideration. An important part… read more here.
Keywords: risks benefits; preference; islet cell; transplantation ... See more keywords
Prognosis for residual islet β‐cell secretion function in young patients with newly diagnosed type 1 diabetes
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DOI: 10.1111/1753-0407.12912
Abstract: This study investigated possible predictors of residual islet β‐cell function (RBF) in young patients with newly diagnosed type 1 diabetes (T1D). read more here.
Keywords: patients newly; newly diagnosed; young patients; residual islet ... See more keywords
Portal flow dynamics after total pancreatectomy and autologous islet cell transplantation
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DOI: 10.1111/ctr.14112
Abstract: Portal vein thrombosis (PVT) is a serious complication of total pancreatectomy and autologous islet cell transplant (TPAIT); therefore, portal flow dynamics are monitored by Doppler ultrasound postoperatively. The practical value of scheduled Doppler ultrasound examinations… read more here.
Keywords: total pancreatectomy; portal flow; autologous islet; flow dynamics ... See more keywords
Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation
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DOI: 10.1111/dom.14177
Abstract: The current study has tested the hypothesis that the positive effects of apelin receptor activation in diabetes are linked to benefits on islet cell apoptosis, proliferation and transdifferentiation using Ins1Cre/+;Rosa26‐eYFP transgenic mice and induction of… read more here.
Keywords: positive effects; actions long; transdifferentiation; beneficial actions ... See more keywords
TERT and Akt Are Involved in the Par-4-Dependent Apoptosis of Islet β Cells in Type 2 Diabetes
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DOI: 10.1155/2018/7653904
Abstract: Islet β cell apoptosis plays an important role in type 2 diabetes. We previously reported that Par-4-mediated islet β cell apoptosis is induced by high-glucose/fatty acid levels. In the present study, we show that Par-4,… read more here.
Keywords: par; apoptosis; islet; cell apoptosis ... See more keywords