Ghrelin regulates the proliferation and apoptosis of high glucose‐induced islet cells through the PI3K–Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Cell Biology International"
DOI: 10.1002/cbin.11981
Abstract: Ghrelin may have therapeutic value in mitigating insulin resistance and type 2 diabetes, based on which we further explore the action mechanism of ghrelin on islet cells in this research. In the course of experiments,… read more here.
Keywords: pi3k akt; islet cells; akt signaling; ghrelin ... See more keywords
PET probes for imaging pancreatic islet cells
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Translational Imaging"
DOI: 10.1007/s40336-017-0251-x
Abstract: PurposePET can detect very low concentrations of the probes at subpicomolar range in the target tissue with high sensitivity. The development of PET probes for imaging pancreatic islet cells depends on several key elements: the… read more here.
Keywords: imaging pancreatic; pancreatic islet; probes imaging; pet probes ... See more keywords
GABA and insulin but not nicotinamide augment α- to β-cell transdifferentiation in insulin-deficient diabetic mice.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2022.115019
Abstract: AIM Poorly controlled diabetes is characterised by a partial or complete loss of pancreatic islet β-cells, which deprives the remaining islet cells of important β-cell-derived soluble signals, such as insulin or GABA. We aimed to… read more here.
Keywords: islet cells; diabetic mice; insulin; cell ... See more keywords
The HETE Is on FFAR1 and Pancreatic Islet Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.01.006
Abstract: It is known but generally unappreciated that the fatty acid receptor FFAR1 (GPR40) is responsible for a major part of glucose-induced insulin secretion. This puzzling fact is now explained by Tunaru et al. (2018), who demonstrate… read more here.
Keywords: pancreatic islet; islet cells; ffar1 pancreatic; hete ffar1 ... See more keywords
Bovine lactoferrin and Lentinus edodes mycelia polysaccharide complex: The formation and the activity to protect islet β cells.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.09.143
Abstract: The formation of complexes may be used for the development of delivery systems in foods field. The aim of this study was to explore the interaction mechanism between Lentinus edodes mycelia polysaccharide (LMP) and bovine… read more here.
Keywords: bovine lactoferrin; lentinus edodes; mycelia polysaccharide; blf ... See more keywords
CRISPR-based genome editing in primary human pancreatic islet cells
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22651-w
Abstract: Gene targeting studies in primary human islets could advance our understanding of mechanisms driving diabetes pathogenesis. Here, we demonstrate successful genome editing in primary human islets using clustered regularly interspaced short palindromic repeats (CRISPR) and… read more here.
Keywords: genome editing; crispr based; islet; editing primary ... See more keywords
Berberine Regulates GPX4 to Inhibit Ferroptosis of Islet β Cells
Sign Up to like & getrecommendations! Published in 2022 at "Planta Medica"
DOI: 10.1055/a-1939-7417
Abstract: Abstract Ferroptosis, as a kind of non-apoptotic cell death, is involved in the pathogenesis of type 1 diabetes mellitus (T1DM). Islet B cells mainly produce insulin that is used to treat diabetes. Berberine (BBR) can… read more here.
Keywords: islet cells; gpx4 inhibit; ferroptosis islet; islet ... See more keywords
BONE MARROW MESENCHYMAL STEM CELLS INHIBIT THE EFFECT OF TIMP3 BY TRANSMITTING MIR-21-5P, THUS IMPROVING THE ANGIOGENESIS OF RAT ISLETS
Sign Up to like & getrecommendations! Published in 2020 at "Transplantation"
DOI: 10.1097/01.tp.0000701604.70883.e5
Abstract: Purpose: Amounts of islet loss in early post-transplantation periods is a major obstacle to achieving favorable results of islet transplantation. Studies have found that bone marrow mesenchymal stem cells (BMSCs) have a protective effect on… read more here.
Keywords: angiogenesis; islet; effect; timp3 ... See more keywords
A 3-Dimensional Coculture Model to Visualize and Monitor Interaction Between Pancreatic Cancer and Islet β Cells
Sign Up to like & getrecommendations! Published in 2021 at "Pancreas"
DOI: 10.1097/mpa.0000000000001865
Abstract: Supplemental digital content is available in the text. Objectives To facilitate exploring a link between pancreatic ductal adenocarcinoma (PDAC) and diabetes mellitus, we constructed a novel 3-dimensional (3D) in vitro coculturing system for studying interactions… read more here.
Keywords: pdac; system; islet; coculture ... See more keywords
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells
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DOI: 10.1098/rsos.160808
Abstract: ATP-sensitive potassium channels (KATP channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, KATP channels are essential for coupling glucose metabolism to insulin secretion. While orthologous genes for many components of metabolism–secretion… read more here.
Keywords: potassium channels; islet; zebrafish islet; islet cells ... See more keywords
Islet β‐cells physiological difference study of old and young mice based on single‐cell transcriptomics
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13579
Abstract: Body aging is a universal biological process. With aging, cells undergo a series of physiological changes. The main feature is cell proliferation decline, although the cells still have normal functions. Pancreatic β‐cells are no exception.… read more here.
Keywords: physiological difference; cells physiological; difference study; islet cells ... See more keywords