MOTS-c modulates pancreatic islet function in rats and pigs in vitro
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DOI: 10.1007/s00418-025-02391-4
Abstract: MOTS-c is a promising regulator of metabolism and energy homeostasis. While its effects have been studied in cell lines, our team aimed to investigate its influence on more complex structures—specifically, isolated pancreatic islets. We used… read more here.
Keywords: modulates pancreatic; function rats; mots modulates; islet function ... See more keywords
Mechanisms of LncRNA FTX in Regulating Islet Function of Pregnant Mice Born With Low-Protein Diet-Induced Intrauterine Growth Retardation
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DOI: 10.1007/s43032-025-01870-2
Abstract: Glucose metabolism during pregnancy in adult females born with intrauterine growth restriction (IUGR) remains inadequately understood. This study aims to investigate how LncRNA FTX regulates islet function during pregnancy in F1 female mice born with… read more here.
Keywords: mice; pregnant mice; mice born; lncrna ftx ... See more keywords
Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2018.07.007
Abstract: BACKGROUND AIMS Mesenchymal stromal cells (MSCs) enhance islet function both in vitro and in vivo, at least in part by secreting ligands that activate islet G-protein coupled receptors (GPCRs). We assessed whether pre-treatment with a… read more here.
Keywords: mesenchymal stromal; islet function; islet; pre ... See more keywords
The role of α-cells in islet function and glucose homeostasis in health and type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.004
Abstract: Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the hypoglycemic action of insulin and strongly contributes to the correction of acute hypoglycemia. The mechanisms by which glucose controls glucagon secretion are… read more here.
Keywords: glucose homeostasis; cells islet; islet function; glucagon ... See more keywords
Effect of artemisinin on improving islet function in rats fed with maternal high-fat diet
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DOI: 10.1080/09513590.2022.2053955
Abstract: Abstract Background Maternal high-fat diet (HFD) is a detrimental factor in developing glucose intolerance, obesity, and islet dysfunction. However, the effect of artemisinin on maternal HFD and whether it is related to the alterations of… read more here.
Keywords: islet function; hfd; high fat; islet ... See more keywords
BETA-2 Score Allows for Convenient and Precise Monitoring of Islet Function and Early Detection of Islet Dysfunction
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DOI: 10.1097/01.tp.0000542654.38281.99
Abstract: Introduction BETA-2 was developed to more conveniently and precisely assess islet graft function than commonly used beta-score, which requires a stimulation test. After validation of BETA-2 in our cohort of patients in relation to 90-min… read more here.
Keywords: insulin; islet function; islet; beta ... See more keywords
The effect of Gegen Qinlian Decoction on clinical prognosis and islet function for type 2 diabetic mellitus
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DOI: 10.1097/md.0000000000024210
Abstract: Abstract Background: With the development of social economy, people's lives are improving day by day. Chronic diseases represented by diabetes have gradually entered people's field of vision. At present, about 415 million people in the… read more here.
Keywords: islet function; islet; effect; prognosis islet ... See more keywords
Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low‐dose enzymes on pancreas digestion and yield
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DOI: 10.1111/ajt.14542
Abstract: A high number of human islets can be isolated by using modern purified tissue dissociation enzymes; however, this requires the use of >20 Wunsch units (WU)/g of pancreas for digestion. Attempts to reduce this dose… read more here.
Keywords: dose; islet function; pancreas digestion; low dose ... See more keywords
Genetic Drivers of Pancreatic Islet Function
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DOI: 10.1534/genetics.118.300864
Abstract: The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the role of islet gene expression in the etiology of diabetes, we sensitized… read more here.
Keywords: pancreatic islet; islet function; islet; expression ... See more keywords
Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis.
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DOI: 10.2337/db22-0399
Abstract: Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can enhance pancreatic islet function in CF… read more here.
Keywords: gip; islet function; glp gip; insulin ... See more keywords
Deleterious Effects of a GAD65 Monoclonal Autoantibody on Islet Function.
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DOI: 10.2337/db25-0475
Abstract: ARTICLE HIGHLIGHTS This study was undertaken to further investigate the ability of a monoclonal autoantibody to GAD65 from a patient with pre-type 1 diabetes to be deleterious to islet function. The study was designed to… read more here.
Keywords: gad65 monoclonal; islet function; effects gad65; monoclonal autoantibody ... See more keywords