Mesenchymal stromal cell secretory factors induce sustained improvements in islet function pre- and post-transplantation.
Sign Up to like & getrecommendations! Published in 2018 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2018.07.007
Abstract: BACKGROUND AIMS Mesenchymal stromal cells (MSCs) enhance islet function both in vitro and in vivo, at least in part by secreting ligands that activate islet G-protein coupled receptors (GPCRs). We assessed whether pre-treatment with a… read more here.
Keywords: mesenchymal stromal; islet function; islet; pre ... See more keywords
The role of α-cells in islet function and glucose homeostasis in health and type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.01.004
Abstract: Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the hypoglycemic action of insulin and strongly contributes to the correction of acute hypoglycemia. The mechanisms by which glucose controls glucagon secretion are… read more here.
Keywords: glucose homeostasis; cells islet; islet function; glucagon ... See more keywords
Effect of artemisinin on improving islet function in rats fed with maternal high-fat diet
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2053955
Abstract: Abstract Background Maternal high-fat diet (HFD) is a detrimental factor in developing glucose intolerance, obesity, and islet dysfunction. However, the effect of artemisinin on maternal HFD and whether it is related to the alterations of… read more here.
Keywords: islet function; hfd; high fat; islet ... See more keywords
BETA-2 Score Allows for Convenient and Precise Monitoring of Islet Function and Early Detection of Islet Dysfunction
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DOI: 10.1097/01.tp.0000542654.38281.99
Abstract: Introduction BETA-2 was developed to more conveniently and precisely assess islet graft function than commonly used beta-score, which requires a stimulation test. After validation of BETA-2 in our cohort of patients in relation to 90-min… read more here.
Keywords: insulin; islet function; islet; beta ... See more keywords
The effect of Gegen Qinlian Decoction on clinical prognosis and islet function for type 2 diabetic mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1097/md.0000000000024210
Abstract: Abstract Background: With the development of social economy, people's lives are improving day by day. Chronic diseases represented by diabetes have gradually entered people's field of vision. At present, about 415 million people in the… read more here.
Keywords: islet function; islet; effect; prognosis islet ... See more keywords
Beneficial effect of recombinant rC1rC2 collagenases on human islet function: Efficacy of low‐dose enzymes on pancreas digestion and yield
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Transplantation"
DOI: 10.1111/ajt.14542
Abstract: A high number of human islets can be isolated by using modern purified tissue dissociation enzymes; however, this requires the use of >20 Wunsch units (WU)/g of pancreas for digestion. Attempts to reduce this dose… read more here.
Keywords: dose; islet function; pancreas digestion; low dose ... See more keywords
Genetic Drivers of Pancreatic Islet Function
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DOI: 10.1534/genetics.118.300864
Abstract: The majority of gene loci that have been associated with type 2 diabetes play a role in pancreatic islet function. To evaluate the role of islet gene expression in the etiology of diabetes, we sensitized… read more here.
Keywords: pancreatic islet; islet function; islet; expression ... See more keywords
Effects of GLP-1 and GIP on Islet Function in Glucose Intolerant, Pancreatic Insufficient Cystic Fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0399
Abstract: Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can enhance pancreatic islet function in CF… read more here.
Keywords: gip; islet function; glp gip; insulin ... See more keywords
New Understanding of β-Cell Heterogeneity and In Situ Islet Function
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DOI: 10.2337/dbi17-0040
Abstract: Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While long known, recent technological advances and new markers have allowed the identification of novel subpopulations, improving our understanding of the molecular basis for heterogeneity.… read more here.
Keywords: islet function; heterogeneity; islet; cell ... See more keywords
Rs864745 in JAZF1, an Islet Function Associated Variant, Correlates With Plasma Lipid Levels in Both Type 1 and Type 2 Diabetes Status, but Not Healthy Subjects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.898893
Abstract: Objective This study aims to reveal the association between JAZF1 rs864745 A>G variant and type 2 diabetes (T2D), type 1 diabetes (T1D) risk, and their correlation with clinical features, including islet function, islet autoimmunity, and… read more here.
Keywords: islet function; plasma lipid; islet; type diabetes ... See more keywords