Differential modulation of IL-12 family cytokines in autoimmune islet graft failure in mice
Sign Up to like & getrecommendations! Published in 2017 at "Diabetologia"
DOI: 10.1007/s00125-017-4418-9
Abstract: Aims/hypothesisThe relative contribution of T helper (Th)1 and Th17 cells in graft rejection is inconclusive, on the basis of evidence provided by different T cell-related cytokine-deficient animal models and graft types.MethodsWe used novel antigen-presenting-cell-specific Il-12p35… read more here.
Keywords: islet graft; graft; cell; graft rejection ... See more keywords
Local Dexamethasone Administration Delays Allogeneic Islet Graft Rejection in the Anterior Chamber of the Eye of Non-Human Primates
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DOI: 10.1177/09636897221098038
Abstract: Pancreatic islet transplantation into the anterior chamber of the eye (ACE) has been shown to improve glycemic control and metabolic parameters of diabetes in both murine and primate models. This novel transplantation site also allows… read more here.
Keywords: islet graft; local dexamethasone; transplantation; islet ... See more keywords
The Spleen Is an Ideal Site for Inducing Transplanted Islet Graft Expansion in Mice
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DOI: 10.1371/journal.pone.0170899
Abstract: Alternative islet transplantation sites have the potential to reduce the marginal number of islets required to ameliorate hyperglycemia in recipients with diabetes. Previously, we reported that T cell leukemia homeobox 1 (Tlx1)+ stem cells in… read more here.
Keywords: islet; islet transplantation; transplantation; site ... See more keywords