Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-12472-3
Abstract: Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and poor angiogenesis. Here, we show that viable and functional islet organoids can… read more here.
Keywords: epithelial cells; amniotic epithelial; treat; islet ... See more keywords
Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cells and development"
DOI: 10.1089/scd.2016.0115
Abstract: Success in the differentiating human embryonic stem cells (hESCs) into insulin-secreting β cells raises new hopes for diabetes treatment. In this work, we demonstrated the feasibility of developing islet organoids from hESCs within biomimetic 3D… read more here.
Keywords: embryonic stem; islet organoids; stem; stem cells ... See more keywords
3D in vivo Magnetic Particle Imaging of Human Stem Cell-Derived Islet Organoid Transplantation Using a Machine Learning Algorithm
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.704483
Abstract: Stem cell-derived islet organoids constitute a promising treatment of type 1 diabetes. A major hurdle in the field is the lack of appropriate in vivo method to determine graft outcome. Here, we investigate the feasibility… read more here.
Keywords: islet; islet organoids; cell derived; stem cell ... See more keywords