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   Articles with "islet organoids" as a keyword



Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-12472-3

Abstract: Maintaining long-term euglycemia after intraportal islet transplantation is hampered by the considerable islet loss in the peri-transplant period attributed to inflammation, ischemia and poor angiogenesis. Here, we show that viable and functional islet organoids can… read more here.

Keywords: epithelial cells; amniotic epithelial; treat; islet ... See more keywords

The porcine islet-derived organoid showed the characteristics as pancreatic duct

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-57059-1

Abstract: Organoid is a tissue-engineered organ-like structure that resemble as an organ. Porcine islet-derived organoid might be used as an alternative donor of porcine islet xenotransplantation, a promising therapy for severe diabetes. In this study, we… read more here.

Keywords: islet organoids; porcine islet; islet derived; islet ... See more keywords

Development of Islet Organoids from H9 Human Embryonic Stem Cells in Biomimetic 3D Scaffolds.

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recommendations! Published in 2017 at "Stem cells and development"

DOI: 10.1089/scd.2016.0115

Abstract: Success in the differentiating human embryonic stem cells (hESCs) into insulin-secreting β cells raises new hopes for diabetes treatment. In this work, we demonstrated the feasibility of developing islet organoids from hESCs within biomimetic 3D… read more here.

Keywords: embryonic stem; islet organoids; stem; stem cells ... See more keywords
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3D in vivo Magnetic Particle Imaging of Human Stem Cell-Derived Islet Organoid Transplantation Using a Machine Learning Algorithm

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recommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2021.704483

Abstract: Stem cell-derived islet organoids constitute a promising treatment of type 1 diabetes. A major hurdle in the field is the lack of appropriate in vivo method to determine graft outcome. Here, we investigate the feasibility… read more here.

Keywords: islet; islet organoids; cell derived; stem cell ... See more keywords

Islet organoids: a new hope for islet transplantation in diabetes

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2024.1540209

Abstract: Diabetes mellitus, including Type 1 diabetes (T1D) and advanced Type 2 diabetes (T2D), remains a major global health challenge due to the destruction or dysfunction of insulin-producing β-cells. Islet transplantation offers a promising therapeutic strategy.… read more here.

Keywords: islet organoids; new hope; organoids new; islet transplantation ... See more keywords