Pancreatic Islet Transcriptional Enhancers and Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Current Diabetes Reports"
DOI: 10.1007/s11892-019-1230-6
Abstract: Common genetic variants that associate with type 2 diabetes risk are markedly enriched in pancreatic islet transcriptional enhancers. This review discusses current advances in the annotation of islet enhancer variants and their target genes. Recent… read more here.
Keywords: pancreatic islet; enhancers diabetes; transcriptional enhancers; islet ... See more keywords
An Early Islet Transcriptional Signature is Associated with Local Inflammation in Autoimmune Diabetes.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes"
DOI: 10.2337/db22-0521
Abstract: Identifying the early islet cellular processes of autoimmune type 1 diabetes (T1D) in humans is challenging given the absence of symptoms during this period and the inaccessibility of the pancreas for sampling. Here, we study… read more here.
Keywords: early islet; autoimmune diabetes; transcriptional signature; islet transcriptional ... See more keywords