Islet Transplantation: Growing Trans‐Species Islets in Tumor Extract‐Remodeled Testicles (Adv. Sci. 6/2019)
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DOI: 10.1002/advs.201970036
Abstract: In article number 1801694, Junfeng Zhang, Chunming Wang, Lei Dong, and co‐workers biochemically remodel one of the two testicles of a mouse into a site that can protect xenogeneic islet cells from immune rejection. The… read more here.
Keywords: growing trans; islet; trans species; transplantation growing ... See more keywords
Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation
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DOI: 10.1002/advs.202411574
Abstract: Islet transplantation offers a promising treatment for type 1 diabetes (T1D), by aiming to restore insulin production and improve glycemic control. However, T1D is compounded by impaired angiogenesis and immune dysregulation, which hinder the therapeutic… read more here.
Keywords: cell; islet; islet transplantation; mesenchymal stem ... See more keywords
Tissue‐engineering approaches in pancreatic islet transplantation
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DOI: 10.1002/bit.26821
Abstract: Pancreatic islet transplantation is a promising alternative to whole‐pancreas transplantation as a treatment of type 1 diabetes mellitus. This technique has been extensively developed during the past few years, with the main purpose of minimizing… read more here.
Keywords: pancreatic islet; islet; islet transplantation; transplantation ... See more keywords
Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation.
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DOI: 10.1002/smll.202202596
Abstract: Islet transplantation is a promising strategy for type 1 diabetes mellitus (T1DM) treatment, whereas implanted-associated foreign body reaction (FBR) usually induces the necrosis of transplanted islets and leads to the failure of glycemic control. Benefiting… read more here.
Keywords: zwitterion; gelma; foreign body; islet transplantation ... See more keywords
eVLP-Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation.
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DOI: 10.1002/smll.202508128
Abstract: Abstract Islet transplantation is a promising strategy for effective β‐cell replacement in patients with type 1 diabetes. However, its success is hindered significantly by instant blood‐mediated inflammatory reaction (IBMIR), which leads to rapid graft loss.… read more here.
Keywords: ibmir; mediated cas9; evlp mediated; islet transplantation ... See more keywords
A silk‐based encapsulation platform for pancreatic islet transplantation improves islet function in vivo
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DOI: 10.1002/term.1990
Abstract: The success of pancreatic islet (PI) transplantation is challenged by PI functional damage during the peritransplantation period. A silk‐based encapsulation platform including mesenchymal stromal cells (MSCs) was evaluated for islet cell delivery in vivo. Islet… read more here.
Keywords: pancreatic islet; islet; silk; islet transplantation ... See more keywords
Islet Transplantation Alone Versus Solitary Pancreas Transplantation: an Outcome-Driven Choice?
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DOI: 10.1007/s11892-019-1145-2
Abstract: Purpose of reviewIn patients with type 1 diabetes with extreme glycemic variability, the restoration of pancreas endocrine function is potentially and completely achieved with islets of Langerhans (tissue derived from whole organ) or pancreas (whole… read more here.
Keywords: outcome driven; islet transplantation; transplantation; transplantation alone ... See more keywords
Injectable hydrogels for islet transplantation: a concise review
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DOI: 10.1007/s40005-019-00433-3
Abstract: Islet cell transplantation is a promising alternative for the treatment of type 1 diabetic mellitus which is caused by complete absence or reduced insulin production by pancreas. After Shapiro and his team carried out successful… read more here.
Keywords: hydrogels islet; injectable hydrogels; islet transplantation; transplantation ... See more keywords
Engineering the vasculature for islet transplantation.
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DOI: 10.1016/j.actbio.2019.05.051
Abstract: The microvasculature in the pancreatic islet is highly specialized for glucose sensing and insulin secretion. Although pancreatic islet transplantation is a potentially life-changing treatment for patients with insulin-dependent diabetes, a lack of blood perfusion reduces… read more here.
Keywords: insulin; islet; vasculature islet; islet transplantation ... See more keywords
A scalable device-less biomaterial approach for subcutaneous islet transplantation.
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DOI: 10.1016/j.biomaterials.2020.120499
Abstract: The subcutaneous space has been shown to be a suitable site for islet transplantation, however an abundance of islets is required to achieve normoglycemia, often requiring multiple donors. The loss of islets is due to… read more here.
Keywords: islet; scalable device; islet transplantation; subcutaneous space ... See more keywords
Reduction of marginal mass required for successful islet transplantation in a diabetic rat model using adipose tissue-derived mesenchymal stromal cells.
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DOI: 10.1016/j.jcyt.2018.06.001
Abstract: BACKGROUND AIMS Adipose tissue-derived mesenchymal stromal cells (AT-MSCs), widely known as multipotent progenitors, release several cytokines that support cell survival and repair. There are in vitro and in vivo studies reporting the regenerative role of… read more here.
Keywords: islet; islet transplantation; transplantation; adipose tissue ... See more keywords