3D Bioprinting of Functional Islets of Langerhans in an Alginate/Methylcellulose Hydrogel Blend.
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DOI: 10.1002/adhm.201801631
Abstract: Transplantation of pancreatic islets is a promising strategy to alleviate the unstable blood-glucose control that some patients with diabetes type 1 exhibit and has seen many advances over the years. Protection of transplanted islets from… read more here.
Keywords: islets langerhans; alginate methylcellulose; bioprinting functional; functional islets ... See more keywords
Method for isolation of pancreatic blood vessels, their culture and coculture with islets of langerhans
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DOI: 10.1002/btpr.2745
Abstract: The only cure available for Type 1 diabetes involves the transplantation of islets of Langerhans isolated from donor organs. However, success rates are relatively low. Disconnection from vasculature upon isolation and insufficient rate of revascularization… read more here.
Keywords: islets langerhans; blood; culture; isolation ... See more keywords
Microwell-based pancreas-on-chip model enhances genes expression and functionality of rat islets of Langerhans
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DOI: 10.1016/j.mce.2020.110892
Abstract: Organ-on-chip technology is a promising tool for investigating physiological in vitro responses in drug screening development, and in advanced disease models. Within this framework, we investigated the behavior of rat islets of Langerhans in an… read more here.
Keywords: islets langerhans; chip model; rat islets; pancreas chip ... See more keywords
State‐of‐the‐art microscopy to understand islets of Langerhans: what to expect next?
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DOI: 10.1111/imcb.12450
Abstract: Abstract The discovery of Langerhans and microscopic description of islets in the pancreas were crucial steps in the discovery of insulin. Over the past 150 years, many discoveries in islet biology and type 1 diabetes… read more here.
Keywords: islets langerhans; microscopy; microscopy understand; biology ... See more keywords
Morphogenesis of the Islets of Langerhans Is Guided by Extraendocrine Slit2 and Slit3 Signals
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DOI: 10.1128/mcb.00451-20
Abstract: The spatial architecture of the islets of Langerhans is vitally important for their correct function, and alterations in islet morphogenesis often result in diabetes mellitus. We have previously reported that Roundabout (Robo) receptors are required… read more here.
Keywords: islet morphogenesis; islets langerhans; morphogenesis; slit2 slit3 ... See more keywords
Axon Guidance Molecules in the Islets of Langerhans
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DOI: 10.3389/fendo.2022.869780
Abstract: The islets of Langerhans, responsible for regulating blood glucose in vertebrates, are clusters of endocrine cells distributed throughout the exocrine pancreas. The spatial architecture of the different cell types within the islets controls cell-cell communication… read more here.
Keywords: cell; islets langerhans; molecules islets; guidance molecules ... See more keywords
From Isles of Königsberg to Islets of Langerhans: Examining the Function of the Endocrine Pancreas Through Network Science
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DOI: 10.3389/fendo.2022.922640
Abstract: Islets of Langerhans are multicellular microorgans located in the pancreas that play a central role in whole-body energy homeostasis. Through secretion of insulin and other hormones they regulate postprandial storage and interprandial usage of energy-rich… read more here.
Keywords: network; function; cell; islets langerhans ... See more keywords
d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans
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DOI: 10.3390/metabo12090799
Abstract: The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide hormones. The structural and chemical characteristics of islets change during type… read more here.
Keywords: cell; islets langerhans; type diabetes; type ... See more keywords
Investigation of the Exometabolomic Profiles of Rat Islets of Langerhans Cultured in Microfluidic Biochip
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DOI: 10.3390/metabo12121270
Abstract: Diabetes mellitus (DM) is a complex disease with high prevalence of comorbidity and mortality. DM is predicted to reach more than 700 million people by 2045. In recent years, several advanced in vitro models and… read more here.
Keywords: investigation exometabolomic; exometabolomic profiles; biochip; islets langerhans ... See more keywords