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   Articles with "ism1" as a keyword



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miR-1307-3p overexpression inhibits cell proliferation and promotes cell apoptosis by targeting ISM1 in colon cancer.

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recommendations! Published in 2019 at "Molecular and cellular probes"

DOI: 10.1016/j.mcp.2019.101445

Abstract: BACKGROUND colon adenocarcinoma (COAD) is the most common malignant tumor of gastrointestinal tract. Our study attempts to explore the effect of miR-1307-3p on biological function of COAD cells and its connection with isthmin 1 (ISM1).… read more here.

Keywords: mir 1307; mir; colon; proliferation ... See more keywords
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Across the adult lifespan the ipsilateral sensorimotor cortex negative BOLD response exhibits decreases in magnitude and spatial extent suggesting declining inhibitory control

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recommendations! Published in 2022 at "NeuroImage"

DOI: 10.1016/j.neuroimage.2022.119081

Abstract: Ipsilateral sensorimotor (iSM1) cortex negative BOLD responses (NBR) are observed to unilateral tasks and are thought to reflect a functionally relevant component of sensorimotor inhibition. Evidence suggests that sensorimotor inhibitory mechanisms degrade with age, along… read more here.

Keywords: sensorimotor; age; response; ism1 ... See more keywords
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ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2019161119

Abstract: Significance Inflammation regulation and homeostasis maintenance is of paramount importance for lung health. Using both genetic and pathological mouse models, this work reveals that the secreted proapoptotic isthmin 1 (ISM1) protects lung homeostasis by controlling… read more here.

Keywords: ism1; copd; apoptosis; lung ... See more keywords
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Isthmin 1 (ism1) is required for normal hematopoiesis in developing zebrafish

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recommendations! Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0196872

Abstract: Hematopoiesis is an essential and highly regulated biological process that begins with hematopoietic stem cells (HSCs). In healthy organisms, HSCs are responsible for generating a multitude of mature blood cells every day, yet the molecular… read more here.

Keywords: hematopoiesis; isthmin ism1; required normal; ism1 ... See more keywords

Circulating Ism1 Reduces the Risk of Type 2 Diabetes but not Diabetes-Associated NAFLD

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recommendations! Published in 2022 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2022.890332

Abstract: Purpose To examine the association of serum Ism1, a new adipokine that can regulate glucose uptake, with type 2 diabetes (T2D) in a Chinese population. Considering high prevalence of Nonalcoholic Fatty Liver Disease in patients… read more here.

Keywords: ism1; diabetes associated; risk; type diabetes ... See more keywords

Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

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recommendations! Published in 2022 at "eLife"

DOI: 10.7554/elife.80014

Abstract: The secreted protein isthmin-1 (Ism1) mitigates diabetes by increasing adipocyte and skeletal muscle glucose uptake by activating the PI3K-Akt pathway. However, while both Ism1 and insulin converge on these common targets, Ism1 has distinct cellular… read more here.

Keywords: muscle protein; ism1; muscle; protein synthesis ... See more keywords