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   Articles with "isoalantolactone" as a keyword



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Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF‐κB/COX‐2‐mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma

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recommendations! Published in 2019 at "Cancer Medicine"

DOI: 10.1002/cam4.2013

Abstract: Isoalantolactone (IATL), a sesquiterpene lactone compound, possesses many pharmacological and biological activities, but its role in glioblastoma (GBM) treatment is still unknown. The aim of the current study was to investigate the antiglioma effects of… read more here.

Keywords: glioblastoma; isoalantolactone; cox; expression ... See more keywords
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Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury

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recommendations! Published in 2018 at "Acta Pharmacologica Sinica"

DOI: 10.1038/s41401-018-0061-3

Abstract: Isoalantolactone (IAL) is a sesquiterpene lactone extracted from roots of Inula helenium L and has shown anti-inflammatory effects. In this study we investigated the therapeutic effects of IAL on acute lung injury (ALI) and elucidated… read more here.

Keywords: lps induced; acute lung; inflammation; isoalantolactone ... See more keywords
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Isoalantolactone mediates the degradation of BCR-ABL protein in imatinib-resistant CML cells by down-regulating survivin.

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recommendations! Published in 2023 at "Cell cycle"

DOI: 10.1080/15384101.2023.2209963

Abstract: Isoalantolactone (Iso) is a bioactive lactone isolated from the root of Inula helenium L, which has been reported to have many pharmacological effects. To investigate the role and mechanism of isoalantolactone in chronic myeloid leukemia… read more here.

Keywords: survivin; resistant cml; isoalantolactone; bcr abl ... See more keywords
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Dual regulation of Akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis

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recommendations! Published in 2023 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.3724/abbs.2023003

Abstract: Ovarian cancer is one of leading causes of cancer death in gynecological tumor. Isoalantolactone (IL), present in several medicinal plants, exhibits various biological activities, and its mechanism underlying anti-ovarian cancer activity needs to be further… read more here.

Keywords: gsh; isoalantolactone; ovarian cancer; growth inhibition ... See more keywords