Iodine(III)‐Mediated Unexpected Ring‐contraction Rearrangement and Halogenated Addition Reaction to Synthesize 3‐Substituted Phthalides and Isochroman‐1‐one Derivatives
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DOI: 10.1002/ejoc.202401173
Abstract: Iodine(III)‐mediated ring‐contraction rearrangement and halogenated addition reaction have been realized. A series of 3‐substituted phthalides and isochroman‐1‐one derivatives bearing multiple functional groups were obtained in good to excellent yields under mild reaction conditions. Computational studies… read more here.
Keywords: reaction; isochroman one; substituted phthalides; iodine iii ... See more keywords
Novel and Potent Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease from Natural (±)-7,8-Dihydroxy-3-methyl-isochroman-4-one
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DOI: 10.3390/molecules27103090
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease that causes memory and cognitive decline as well as behavioral problems. It is a progressive and well recognized complex disease; therefore, it is very urgent to develop novel… read more here.
Keywords: disease; alzheimer disease; dihydroxy methyl; natural dihydroxy ... See more keywords