Characterization of the nicotinamide adenine dinucleotides (NAD+ and NADP+) binding sites of the monomeric isocitrate dehydrogenases from Campylobacter species.
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DOI: 10.1016/j.biochi.2019.03.007
Abstract: Monomeric isocitrate dehydrogenases (IDHs) have once been proposed to be exclusively NADP+-specific. Intriguingly, we recently have reported an NAD+-specific monomeric IDH from Campylobacter sp. FOBRC14 (CaIDH). Moreover, bioinformatic analysis revealed at least three different coenzyme-binding… read more here.
Keywords: nad nadp; isocitrate; nadp binding; ccidh ... See more keywords
The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
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DOI: 10.1038/srep41882
Abstract: Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. To explore the functional roles of… read more here.
Keywords: dependent isocitrate; human nad; nad dependent; isocitrate dehydrogenase ... See more keywords
Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
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DOI: 10.1126/sciadv.aaw4543
Abstract: We review the contribution of altered isocitrate dehydrogenase activity to the pathogenesis of a broad spectrum of human disease. Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate… read more here.
Keywords: isocitrate; isocitrate dehydrogenases; cancer associated; biology ... See more keywords
Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH)
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DOI: 10.1371/journal.pgen.1006975
Abstract: DJ-1 is one of the causative genes for early onset familiar Parkinson’s disease (PD) and is also considered to influence the pathogenesis of sporadic PD. DJ-1 has various physiological functions which converge on controlling intracellular… read more here.
Keywords: dependent isocitrate; isocitrate; nadp dependent; idh ... See more keywords
Wild-Type Isocitrate Dehydrogenase-Dependent Oxidative Decarboxylation and Reductive Carboxylation in Cancer and Their Clinical Significance
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DOI: 10.3390/cancers14235779
Abstract: Simple Summary While isocitrate dehydrogenases have been known for decades, their mechanisms in tumors are gradually becoming clearer. The three isocitrate dehydrogenase isoforms in human cells differ in their subcellular localization, molecular structure, cofactor requirement,… read more here.
Keywords: isocitrate dehydrogenase; oxidative decarboxylation; cancer; isocitrate ... See more keywords
Stochastic Microsensors Based on Carbon Nanotubes for Molecular Recognition of the Isocitrate Dehydrogenases 1 and 2
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DOI: 10.3390/nano12030460
Abstract: Two three-dimensional (3D) stochastic microsensors based on immobilization of protoporphyrin IX (PIX) in single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT) decorated with copper (Cu) and gold (Au) nanoparticles were designed and used for… read more here.
Keywords: stochastic microsensors; molecular recognition; carbon nanotubes; isocitrate ... See more keywords