Isocitrate dehydrogenase 1 sustains a hybrid cytoplasmic-mitochondrial tricarboxylic acid cycle that can be targeted for therapeutic purposes in prostate cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13441
Abstract: The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1) but not its mitochondrial counterparts… read more here.
Keywords: cycle; prostate cancer; idh1; isocitrate dehydrogenase ... See more keywords
Isocitrate dehydrogenase‐mutant glioma: Evolving clinical and therapeutic implications
Sign Up to like & getrecommendations! Published in 2017 at "Cancer"
DOI: 10.1002/cncr.31039
Abstract: The metabolic genes isocitrate dehydrogenase 1 (IDH1) and IDH2 are commonly mutated in low‐grade glioma and in a subset of glioblastoma. These mutations co‐occur with other recurrent molecular alterations, including 1p/19q codeletions and tumor suppressor… read more here.
Keywords: glioma; isocitrate dehydrogenase; idh; mutant glioma ... See more keywords
Application of denaturing capillary electrophoresis for the detection of prognostic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes in brain tumors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201701473
Abstract: Malignant transformation in gliomas is frequently supplemented by somatic mutations in isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 genes. It has recently emerged that mutations in these genes are associated with prolonged survival and should… read more here.
Keywords: capillary electrophoresis; dehydrogenase; detection; isocitrate dehydrogenase ... See more keywords
Improving D-2-hydroxyglutarate MR spectroscopic imaging in mutant isocitrate dehydrogenase glioma patients with multiplexed RF-receive/B0 -shim array coils at 3 T.
Sign Up to like & getrecommendations! Published in 2021 at "NMR in biomedicine"
DOI: 10.1002/nbm.4621
Abstract: MR spectroscopic imaging (MRSI) noninvasively maps the metabolism of human brains. In particular, the imaging of D-2-hydroxyglutarate (2HG) produced by glioma isocitrate dehydrogenase (IDH) mutations has become a key application in neuro-oncology. However, the performance… read more here.
Keywords: glioma patients; spectroscopic imaging; array coils; glioma ... See more keywords
Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-018-2627-3
Abstract: PurposeThe myelodysplastic syndromes (MDS) are a group of hematologic disorders characterized by the presence of somatically mutated hematopoietic stem cells (HSCs) that increase the risk of progression to secondary acute myeloid leukemia (sAML). Mutations in… read more here.
Keywords: leukemic transformation; myelodysplastic syndromes; risk; isocitrate dehydrogenase ... See more keywords
R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary Research Communications"
DOI: 10.1007/s11259-017-9707-8
Abstract: Glioma is the second most common intracranial neoplasia in dogs, but the pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 1 (IDH1) is frequently mutated in gliomas. Although almost all human IDH1 mutations have been… read more here.
Keywords: r132h; isocitrate dehydrogenase; dehydrogenase idh1; r132s ... See more keywords
Isocitrate dehydrogenase gene mutations and 2-hydroxyglutarate accumulation in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Medical Oncology"
DOI: 10.1007/s12032-018-1229-x
Abstract: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to α-ketoglutarate. Somatic point mutations in IDH1/2 confer a gain-of-function in cancer cells, resulting in overproduction of an oncometabolite, 2-hydroxyglutarate… read more here.
Keywords: esophageal squamous; idh1 idh2; isocitrate dehydrogenase; idh2 mutations ... See more keywords
Association between Genetic Variations of Mitochondrial Isocitrate Dehydrogenase (IDH2) and Acute Myocardial Infarction.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146497
Abstract: PURPOSE Mitochondrial isocitrate dehydrogenase (IDH2) is a major contributor to cellular redox control. The aim of this study was to preliminary link IDH2 genetic variations to redox imbalance, atherogenesis and risk of acute myocardial infarction… read more here.
Keywords: genetic variations; dehydrogenase idh2; mitochondrial isocitrate; idh2 ... See more keywords
Imaging Findings of New Entities and Patterns in Brain Tumor: Isocitrate Dehydrogenase Mutant, Isocitrate Dehydrogenase Wild-Type, Codeletion, and MGMT Methylation.
Sign Up to like & getrecommendations! Published in 2021 at "Radiologic clinics of North America"
DOI: 10.1016/j.rcl.2021.01.001
Abstract: Molecular features are now essential in distinguishing between glioma histologic subtypes. Currently, isocitrate dehydrogenase mutation, 1p19q codeletion, and MGMT methylation status play significant roles in optimizing medical and surgical treatment. Noninvasive pretreatment and post-treatment determination… read more here.
Keywords: codeletion mgmt; dehydrogenase; isocitrate dehydrogenase; imaging findings ... See more keywords
Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00636
Abstract: Human isocitrate dehydrogenase 1 (IDH1) is a highly conserved metabolic enzyme that catalyzes the interconversion of isocitrate and α-ketoglutarate. Kinetic and structural studies with IDH1 have revealed evidence of striking conformational changes that occur upon… read more here.
Keywords: dehydrogenase idh1; isocitrate dehydrogenase; conformational changes; human isocitrate ... See more keywords
Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.3c00203
Abstract: Isocitrate dehydrogenase (IDH) 1/2 gain-of-function variants catalyze the production of the oncometabolite 2-hydroxyglutarate and are validated targets for leukemia treatment. We report binding and inhibition studies on 13 IDH1/2 variant inhibitors, including clinical candidates and… read more here.
Keywords: inhibition selectivity; binding affinity; inhibition; idh1 ... See more keywords