Two phylogenetically divergent isocitrate dehydrogenases are encoded in Leishmania parasites. Molecular and functional characterization of Leishmania mexicana isoenzymes with specificity towards NAD+ and NADP.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Biochemical Parasitology"
DOI: 10.1016/j.molbiopara.2020.111320
Abstract: Abstract Leishmania parasites are of great relevance to public health because they are the causative agents of various long-term and health-threatening diseases in humans. Dependent on the manifestation, drugs either require difficult and lengthy administration,… read more here.
Keywords: isocitrate dehydrogenases; leishmania parasites; idhs; idh ... See more keywords
Cancer-associated mutation and beyond: The emerging biology of isocitrate dehydrogenases in human disease
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DOI: 10.1126/sciadv.aaw4543
Abstract: We review the contribution of altered isocitrate dehydrogenase activity to the pathogenesis of a broad spectrum of human disease. Isocitrate dehydrogenases (IDHs) are critical metabolic enzymes that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate… read more here.
Keywords: isocitrate; isocitrate dehydrogenases; cancer associated; biology ... See more keywords
Expression and Characterization of Monomeric Recombinant Isocitrate Dehydrogenases from Corynebacterium glutamicum and Azotobacter vinelandii for NADPH Regeneration
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315318
Abstract: The enzymatic transformation of various chemicals, especially using NADPH-dependent hydroxylase, into more soluble and/or high value-added products has steadily garnered increasing attention. However, the industrial application of these NADPH-dependent hydroxylases has been limited due to… read more here.
Keywords: regeneration; corynebacterium glutamicum; isocitrate dehydrogenases; nadph regeneration ... See more keywords