Active Site Flexibility of Mycobacterium tuberculosis Isocitrate Lyase in Dimer Form.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00265
Abstract: Tuberculosis (TB) still remains a global threat due to the emergence of a drug-resistant strain. Instead of focusing on the drug target of active stage TB, we are highlighting the isocitrate lyase (ICL) at the… read more here.
Keywords: icl; isocitrate lyase; active site; site ... See more keywords
Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01235-z
Abstract: Isocitrate lyase (ICL), a potential anti-tubercular drug target, catalyzes the first step of the glyoxylate shunt. In the present investigation, we studied the conformational flexibility of MtbICL to better understand its stability and catalytic activity.… read more here.
Keywords: isocitrate lyase; flexibility; structural flexibility; stability ... See more keywords
Characterization of a salt-resistant isocitrate lyase gene from mangrove wetland using shotgun metagenomic sequencing.
Sign Up to like & getrecommendations! Published in 2023 at "Letters in applied microbiology"
DOI: 10.1093/lambio/ovad044
Abstract: Isocitrate lyase, as the key enzyme in the glyoxylate metabolic pathway, plays an important role in metabolic adaptation to environmental changes. In this study, metagenomic DNA from the soil and water microorganism collected from the… read more here.
Keywords: isocitrate lyase; salt resistant; gene; characterization salt ... See more keywords
Discovery of a Novel Inhibitor Structure of Mycobacterium tuberculosis Isocitrate Lyase
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082447
Abstract: Tuberculosis remains a global threat to public health, and dormant Mycobacterium tuberculosis leads to long-term medication that is harmful to the human body. M. tuberculosis isocitrate lyase (MtICL), which is absent in host cells, is… read more here.
Keywords: tuberculosis; mycobacterium tuberculosis; isocitrate lyase; tuberculosis isocitrate ... See more keywords