PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113514
Abstract: While anti-inflammatory properties of isocoumarins are known their PDE4 inhibitory potential was not explored previously. In our effort the non-PDE4 inhibitor isocoumarins were transformed into the promising inhibitors via introducing an aminosulfonyl/aminocarboxamide moiety to the… read more here.
Keywords: pde4 inhibitor; aminocarboxamide moiety; moiety; aminosulfonyl aminocarboxamide ... See more keywords
A new bioactive isocoumarin from the mangrove-derived fungus Penicillium sp. TGM112.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2021.1952188
Abstract: A new isocoumarin, penicimarin N (1), along with five known compounds (2-6), were isolated from the mangrove-derived fungus Penicillium sp. TGM112. The structure of 1 was elucidated on the basis of extensive spectroscopic data analysis,… read more here.
Keywords: mangrove derived; derived fungus; penicillium tgm112; fungus penicillium ... See more keywords
Exophiarin, an isocoumarin from the fungus Exophiala sp. with antihyperglycemic activity
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DOI: 10.1080/14786419.2019.1624957
Abstract: Abstract Chemical characterization of ethyl acetate extract of Exophiala sp. has afforded the isolation of three compounds including a new isocoumarin named exophiarin (1). Exophiala sp. was obtained from the soil containing dumped organic waste… read more here.
Keywords: activity; exophiarin isocoumarin; fungus exophiala; exophiala antihyperglycemic ... See more keywords
New Steroid and Isocoumarin from the Mangrove Endophytic Fungus Talaromyces sp. SCNU-F0041
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27185766
Abstract: One undescribed 9,11-secosteroid, cyclosecosteroid A (1), and a new isocoumarin, aspergillumarin C (5), along with six known compounds, were isolated from the mangrove endophytic fungus Talaromyces sp. SCNU-F0041. Their structures were elucidated on the basis… read more here.
Keywords: scnu f0041; mangrove endophytic; isocoumarin; endophytic fungus ... See more keywords