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Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700826
Abstract: The present work discloses an efficient multicomponent reaction of isocyanide, allenoate, and indole. In the absence of any catalyst, this protocol provides a rapid and direct access to furnish N-H functionalization of indole from readily…
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Keywords:
isocyanide based;
functionalization indole;
multicomponent reaction;
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Published in 2020 at "Amino acids"
DOI: 10.1007/s00726-020-02917-1
Abstract: Isocyanide-based consecutive Bargellini/Ugi multicomponent reactions as a combinatorial strategy have been developed for the synthesis of new class of pseudo-peptides. Via Bargellini reaction 3-carboxamido-isobutyric acids are prepared using acetone, chloroform, sodium hydroxide, and isocyanides. Then,…
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Keywords:
pseudo;
pseudo peptides;
based consecutive;
bargellini ugi ... See more keywords
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Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01792
Abstract: A highly enantioselective isocyanide-based multicomponent reaction catalyzed by a chiral N,N'-dioxide/MgII complex was reported. A wide range of substrates were tolerated in this reaction, including alkyl- and aryl-substituted isocyanides with alkylidene malonates and various phenols,…
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Keywords:
multicomponent reaction;
alkylidene malonates;
enantioselective isocyanide;
reaction ... See more keywords
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Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02316
Abstract: A Co-catalyzed cyclization reaction of isocyanides, azides, and amines to access quinazoline derivatives was described. This protocol features a high atom economy, mild reaction conditions, excellent yields, and a broad substrate scope. This cascade reaction…
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Keywords:
based three;
cobalt catalyzed;
three component;
reaction ... See more keywords
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Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09904-5
Abstract: Although isocyanide-based multicomponent reactions were proven to be simple, elegant and facile strategies for the synthesis of highly valuable nitrogen-containing heterocycles, their asymmetric versions accessing to optically active nitrogen heterocyclic compounds are rather limited. Here,…
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Keywords:
multicomponent reactions;
synthesis tetrazole;
reaction;
asymmetric synthesis ... See more keywords
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Published in 2018 at "Synthesis"
DOI: 10.1055/s-0037-1610540
Abstract: A variety of perfluoroalkyl-substituted γ-spiroiminolactones have been synthesized via a one-pot, three-component cascade reaction in which isocyanides, methyl perfluoroalk-2-ynoates and 1,2-diketones undergo highly regioselective Michael addition, nucleophilic addition and cyclization. This reaction has the advantages…
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Keywords:
perfluroalkyl ated;
straightforward access;
mcrs straightforward;
based mcrs ... See more keywords
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Published in 2020 at "Synthesis"
DOI: 10.1055/s-0040-1706297
Abstract: Lactams are very important heterocycles as a result of their presence in a wide range of bioactive molecules, natural products and drugs, and also due their utility as versatile synthetic intermediates. Due to these reasons,…
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Keywords:
multicomponent reactions;
lactams lactams;
isocyanide based;
based multicomponent ... See more keywords
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Published in 2023 at "Current organic synthesis"
DOI: 10.2174/1570179420666230330170845
Abstract: BACKGROUND Isocyanide is an intriguing one-carbon synthon that is frequently employed in a variety of carbon-carbon and carbon-heteroatom bond-forming reactions. Isocyanide-based multicomponent reactions (IMCRs) are effective synthetic tools in organic synthesis for the preparation of…
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Keywords:
isocyanide based;
multicomponent reactions;
reactions imcrs;
water ... See more keywords
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Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12050849
Abstract: Multicomponent reactions (MCR) have been used to synthesize a wide range of analogs from several classes of heterocyclic compounds, with multifaceted medicinal uses. The synthesis of highly functionalized molecules in a single pot is a…
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Keywords:
novel antimicrobial;
isocyanide based;
discovery novel;
multicomponent reactions ... See more keywords