Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long‐term modifications in corpus callosum microstructural integrity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24343
Abstract: Isoflurane is a commonly used inhalational anesthetic, clinically and in animal experimental studies. Although it has been reported as safe, recent findings suggest that despite widespread use, isoflurane‐induced inhalational anesthesia can lead to various pathophysiological… read more here.
Keywords: long term; repeated isoflurane; exposure; mice ... See more keywords
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05287-z
Abstract: RationaleThe volatile anesthetic isoflurane is suggested to produce a rapid and robust antidepressive effect in preliminary clinical trials. Recently, isoflurane was found to activate the tropomyosin receptor kinase B (TrkB) signaling which is the underlying… read more here.
Keywords: trkb signaling; effect; bdnf trkb; isoflurane ... See more keywords
Lidocaine Attenuates Cognitive Impairment After Isoflurane Anesthesia by Reducing Mitochondrial Damage
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02799-0
Abstract: Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in isoflurane-induced neuronal damage. Lidocaine has been demonstrated to attenuate the impairment of cognition in aged rats induced by isoflurane in our… read more here.
Keywords: mitochondrial damage; cognitive impairment; lidocaine; damage ... See more keywords
Influence of Isoflurane Exposure for 15 Consecutive Days on Ovarian Function in Adult Female Mice
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DOI: 10.1007/s11596-020-2300-3
Abstract: Female infertility after occupational exposure to inhaled anesthetic agents has attracted critical attention, but systematic studies focusing on the impact of inhaled anesthetics on the female reproductive system have not been well-established. We used a… read more here.
Keywords: exposure; adult female; mice; isoflurane exposure ... See more keywords
The Protective Effects of Ramelteon Against Isoflurane-Induced Insults and Inflammatory Response in Brain Microvascular Endothelial Cells.
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DOI: 10.1007/s12640-020-00309-7
Abstract: Anesthetic-induced cognitive impairment has been observed clinically. The mechanism underlying anesthetic-induced cognitive impairment is closely associated with neuronal apoptosis and neuroinflammation. Ramelteon is a potent and highly selective melatonin receptor agonist that has been used… read more here.
Keywords: brain microvascular; isoflurane induced; microvascular endothelial; endothelial cells ... See more keywords
Anti-RAGE antibody attenuates isoflurane-induced cognitive dysfunction in aged rats
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DOI: 10.1016/j.bbr.2017.01.012
Abstract: HighlightsIsoflurane exposure induced impairment of hippocampus‐dependent spatial learning and memory in aged rats.RAGE antibody administration improve the BBB disruption, reduce the neuroinflamation and A&bgr; deposition.RAGE antibody administration attenuated the cognitive impairment induced by isoflurane exposure.… read more here.
Keywords: aged rats; exposure; rage; isoflurane ... See more keywords
Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.09.004
Abstract: HIGHLIGHTSIsoflurane treatment resulted in the reversible hippocampus BBB disruption in aged rats of POCD.BBB disruption is likely related to activation of HIF‐1&agr;/VEGF‐MMPs pathways during isoflurane exposure.HIF‐1&agr; inhibition could mitigate isoflurane‐induced cognitive impairment in aged rats… read more here.
Keywords: isoflurane; isoflurane induced; disruption; hif agr ... See more keywords
Evaluation of prolonged administration of isoflurane on cerebral blood flow and default mode network in macaque monkeys anesthetized with different maintenance doses
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DOI: 10.1016/j.neulet.2017.10.034
Abstract: OBJECT Isoflurane is a commonly used volatile anesthetic agent in clinical anesthesia and biomedical research. Prior study suggested the cerebral blood flow (CBF) and default mode network (DMN) could be changed after prolonged administration of… read more here.
Keywords: administration; administration isoflurane; maintenance doses; prolonged administration ... See more keywords
Isoflurane versus sevoflurane for early brain injury and expression of sphingosine kinase 1 after experimental subarachnoid hemorrhage
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135142
Abstract: The first step to treat aneurysmal subarachnoid hemorrhage (SAH) is aneurysmal obliteration under general anesthesia but not treat the SAH itself and the secondary effects. However, the identification of anesthetics with properties that help to… read more here.
Keywords: subarachnoid hemorrhage; isoflurane; brain injury; brain ... See more keywords
Isoflurane affects brain functional connectivity in rats 1 month after exposure
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DOI: 10.1016/j.neuroimage.2021.117987
Abstract: Isoflurane, the most commonly used preclinical anesthetic, induces brain plasticity and long-term cellular and molecular changes leading to behavioral and/or cognitive consequences. These changes are most likely associated with network-level changes in brain function. To… read more here.
Keywords: exposure; expression; isoflurane; brain ... See more keywords
Emulsified isoflurane induces release of cytochrome C in human neuroblastoma SHSY-5Y cells via JNK (c-Jun N-terminal kinases) signaling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2017.12.001
Abstract: A large number of studies have demonstrated that inhalation anesthetic isoflurane induced neural cell death by apoptosis in various cell and animal models. Emulsified isoflurane (EIso) is a new type of intravenous preparation of isoflurane… read more here.
Keywords: jnk; shsy cells; human neuroblastoma; neuroblastoma shsy ... See more keywords