The Protective Effects of Ramelteon Against Isoflurane-Induced Insults and Inflammatory Response in Brain Microvascular Endothelial Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Neurotoxicity research"
DOI: 10.1007/s12640-020-00309-7
Abstract: Anesthetic-induced cognitive impairment has been observed clinically. The mechanism underlying anesthetic-induced cognitive impairment is closely associated with neuronal apoptosis and neuroinflammation. Ramelteon is a potent and highly selective melatonin receptor agonist that has been used… read more here.
Keywords: brain microvascular; isoflurane induced; microvascular endothelial; endothelial cells ... See more keywords
Hypoxia-inducible factor-1α is involved in isoflurane-induced blood-brain barrier disruption in aged rats model of POCD
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.09.004
Abstract: HIGHLIGHTSIsoflurane treatment resulted in the reversible hippocampus BBB disruption in aged rats of POCD.BBB disruption is likely related to activation of HIF‐1&agr;/VEGF‐MMPs pathways during isoflurane exposure.HIF‐1&agr; inhibition could mitigate isoflurane‐induced cognitive impairment in aged rats… read more here.
Keywords: isoflurane; isoflurane induced; disruption; hif agr ... See more keywords
Carbon monoxide incompletely prevents isoflurane-induced defects in murine neurodevelopment.
Sign Up to like & getrecommendations! Published in 2017 at "Neurotoxicology and teratology"
DOI: 10.1016/j.ntt.2017.01.004
Abstract: BACKGROUND Commonly used anesthetics have been shown to disrupt neurodevelopment in preclinical models. It has been proposed that such anesthesia-induced neurotoxicity is mediated by apoptotic neurodegeneration in the immature brain. Low dose carbon monoxide (CO)… read more here.
Keywords: induced defects; isoflurane induced; brain; carbon monoxide ... See more keywords
The protective effect of trilobatin against isoflurane-induced neurotoxicity in mouse hippocampal neuronal HT22 cells involves the Nrf2/ARE pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology"
DOI: 10.1016/j.tox.2020.152537
Abstract: Long-term exposure to isoflurane may induce long-term developmental neurotoxicity and cognitive impairments in the neonatal brains. Trilobatin, a leaf extract from the Chinese traditional sweet tea Lithocarpus polystachyus Rehd, possesses various biological properties including anti-inflammatory… read more here.
Keywords: ht22 cells; isoflurane induced; neurotoxicity; trilobatin ... See more keywords
Beclin1-mediated ferroptosis activation is associated with isoflurane-induced toxicity in SH-SY5Y neuroblastoma cells.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmz104
Abstract: The widely used inhalation anesthetic, isoflurane, potentially induces neuronal injury in clinical practice. Previous studies showed multiple forms of cell death that resulted from isoflurane-induced cytotoxicity, but the precise underlying mechanism remains poorly understood. Ferroptosis… read more here.
Keywords: sy5y neuroblastoma; ferroptosis; isoflurane induced; induced toxicity ... See more keywords
Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1137-1
Abstract: BackgroundElderly patients are more likely to suffer from postoperative cognitive dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the particular pathogenesis of POCD in elderly patients remains unknown. This study is carried… read more here.
Keywords: nlrp3 caspase; caspase pathway; isoflurane induced; cognitive impairment ... See more keywords
Neuroprotective effects of dexmedetomidine against isoflurane-induced neuronal injury via glutamate regulation in neonatal rats
Sign Up to like & getrecommendations! Published in 2019 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s163197
Abstract: Background Considerable evidences support the finding that the anesthesia reagent isoflurane increases neuronal cell death in young rats. Recent studies have shown that dexmedetomidine can reduce isoflurane-induced neuronal injury, but the mechanism remains unclear. We… read more here.
Keywords: dexmedetomidine isoflurane; induced neuronal; neuronal injury; isoflurane induced ... See more keywords
Mild Hypothermia Attenuates the Anesthetic Isoflurane-Induced Cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00015
Abstract: The commonly used inhalation anesthetic isoflurane has been reported to induce DNA damage and cytotoxicity. However, the methods to attenuate these effects remain largely to be determined. Mild hypothermia has neuroprotective effects. We therefore set… read more here.
Keywords: dna damage; mild hypothermia; isoflurane induced; isoflurane ... See more keywords
Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00368
Abstract: Neonatal exposure to isoflurane can result in neuroapoptosis and persistent cognitive impairments. However, the underlying mechanisms remain elusive. Anaphase-promoting complex/cyclosome (APC/C) and its co-activator Cdh1 are E3 ubiquitin ligases that play important roles in the… read more here.
Keywords: cdh1; neuronal apoptosis; isoflurane induced; developing rats ... See more keywords
CHIP Decline Is Associated With Isoflurane-Induced Neurodegeneration in Aged Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.824871
Abstract: Perioperative neurocognitive disorders (PND) commonly occur in elderly patients, and isoflurane could be a risk factor. During the pathogenesis of neurodegeneration, the ubiquitin–proteasome system (UPS) participates in the process of aging, which affects synaptic plasticity… read more here.
Keywords: decline; aged mice; neurodegeneration; isoflurane induced ... See more keywords
Downregulation of microRNA-448 improves isoflurane-induced learning and memory impairment in rats.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6724
Abstract: The present study aimed to investigate the potential role of microRNA‑448 (miR‑448) in isoflurane-induced learning and memory impairment in rats. Sprague‑Dawley rats were used for the construction of isoflurane‑treated models. The Morris water maze test… read more here.
Keywords: memory impairment; learning memory; isoflurane induced; mir 448 ... See more keywords