Cancer cell‐derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5601
Abstract: It recently has been reported that partial‐epithelial–mesenchymal transition (p‐EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). We previously have identified POSTN (which encodes periostin) as an invasion‐promoting molecule in… read more here.
Keywords: cell; postn; iso5; isoform ... See more keywords
ERK1b, a 46‐kDa ERK isoform that is differentially regulated by MEK
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11801
Abstract: The extracellular signal‐regulated kinases (ERK) 1 and 2 (ERK1/2) are members of the mitogen‐activated protein kinase family. Using various stimulated rodent cells and kinase activation techniques, we identified a 46‐kDa ERK. The kinetics of activation… read more here.
Keywords: erk isoform; erk1 erk2; isoform; erk1b ... See more keywords
PTPN21‐CDSlong isoform inhibits the response of acute lymphoblastic leukemia cells to NK‐mediated lysis via the KIR/HLA‐I axis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29601
Abstract: Protein tyrosine phosphatase non‐receptor type 21 (PTPN21) is a member of the non‐receptor tyrosine phosphatase family. We have found that PTPN21 is mutated in relapsed Philadelphia chromosome‐negative acute lymphoblastic leukemia (ALL) after allogeneic hematopoietic stem… read more here.
Keywords: ptpn21; isoform; lymphoblastic leukemia; cells mediated ... See more keywords
Somatic A‐to‐I RNA‐edited RHOA isoform 2 specific‐R176G mutation promotes tumor progression in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23490
Abstract: Adenosine‐to‐inosine (A‐to‐I) RNA editing is the most common posttranscriptional editing to create somatic mutations and increase proteomic diversity. However, the functions of the edited mutations are largely underexplored. To identify novel targets in lung adenocarcinoma… read more here.
Keywords: r176g mutation; rna; isoform; rhoa isoform ... See more keywords
Advancing physiological maturation in human induced pluripotent stem cell‐derived cardiac muscle by gene editing an inducible adult troponin isoform switch
Sign Up to like & getrecommendations! Published in 2020 at "STEM CELLS"
DOI: 10.1002/stem.3235
Abstract: Advancing maturation of stem cell‐derived cardiac muscle represents a major barrier to progress in cardiac regenerative medicine. Cardiac muscle maturation involves a myriad of gene, protein, and cell‐based transitions, spanning across all aspects of cardiac… read more here.
Keywords: adult; isoform; cardiac muscle; maturation ... See more keywords
In Vivo Phosphorylation: Development of Specific Antibodies to Detect the Phosphorylated PEPC Isoform for the C4 Photosynthesis in Zea mays.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9865-4_18
Abstract: Phosphoenolpyruvate carboxylases (PEPCs), mostly known as the enzymes responsible for the initial CO2 fixation during C4 photosynthesis, are regulated by reversible phosphorylation in vascular plants. The phosphorylation site on a PEPC molecule is conserved not… read more here.
Keywords: phosphorylated pepc; phosphorylation development; isoform; photosynthesis ... See more keywords
Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
Sign Up to like & getrecommendations! Published in 2018 at "Diabetologia"
DOI: 10.1007/s00125-018-4704-1
Abstract: Aims/hypothesisThe Coxsackie and adenovirus receptor (CAR) is a transmembrane cell-adhesion protein that serves as an entry receptor for enteroviruses and may be essential for their ability to infect cells. Since enteroviral infection of beta cells… read more here.
Keywords: beta cells; isoform; car siv; car ... See more keywords
Human variability in isoform-specific UDP-glucuronosyltransferases: markers of acute and chronic exposure, polymorphisms and uncertainty factors
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02765-8
Abstract: UDP-glucuronosyltransferases (UGTs) are involved in phase II conjugation reactions of xenobiotics and differences in their isoform activities result in interindividual kinetic differences of UGT probe substrates. Here, extensive literature searches were performed to identify probe… read more here.
Keywords: uncertainty; uncertainty factors; isoform; probe substrates ... See more keywords
Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases
Sign Up to like & getrecommendations! Published in 2019 at "Acta Neuropathologica"
DOI: 10.1007/s00401-019-02109-6
Abstract: Developmental and/or epileptic encephalopathies (DEEs) are a group of devastating genetic disorders, resulting in early-onset, therapy-resistant seizures and developmental delay. Here we report on 22 individuals from 15 families presenting with a severe form of… read more here.
Keywords: isoform; isoform specific; start loss; specific start ... See more keywords
WhichP450: a multi-class categorical model to predict the major metabolising CYP450 isoform for a compound
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0107-0
Abstract: In the development of novel pharmaceuticals, the knowledge of how many, and which, Cytochrome P450 isoforms are involved in the phase I metabolism of a compound is important. Potential problems can arise if a compound… read more here.
Keywords: model predict; isoform; major metabolising; model ... See more keywords
C/EBPß Isoform Specific Gene Regulation: It’s a Lot more Complicated than you Think!
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-020-09444-5
Abstract: It has been almost 30 years since C/EBPß was discovered. Seminal studies have shown that C/EBPß is a master regulator of mammary gland development and has been shown to control and influence proliferation and differentiation through… read more here.
Keywords: ebp isoform; isoform; isoform specific; breast cancer ... See more keywords