Regulation of Isoform Expression by Blocking Polyadenylation Signal Sequences with Morpholinos.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6817-6_12
Abstract: Alternative polyadenylation is increasingly being recognized as an important layer of gene regulation. Antisense-mediated modulation of alternative polyadenylation represents an attractive strategy for the regulation of gene expression as well as potential therapeutic applications. In… read more here.
Keywords: expression blocking; isoform expression; polyadenylation; polyadenylation signal ... See more keywords
Chronic Ethanol Consumption Alters Glucocorticoid Receptor Isoform Expression in Stress Neurocircuits and Mesocorticolimbic Brain Regions of Alcohol-Preferring Rats
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2020.04.033
Abstract: Evidence suggests the hypothalamic-pituitary-adrenal (HPA) axis is involved in Alcohol Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor (GR), GRα and GRβ, activity. GRβ antagonizes the GRα isoform to cause… read more here.
Keywords: isoform expression; ethanol drinking; expression; alcohol preferring ... See more keywords
ScisorWiz: visualizing differential isoform expression in single-cell long-read data
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac340
Abstract: RNA isoforms contribute to the diverse functionality of the proteins they encode within the cell. Visualizing how isoform expression differs across cell types and brain regions can inform our understanding of disease and gain or… read more here.
Keywords: differential isoform; cell; single cell; isoform expression ... See more keywords
Temperature-induced changes in Arabidopsis Rubisco activity and isoform expression
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DOI: 10.1093/jxb/erac379
Abstract: Abstract In many plant species, expression of the nuclear encoded Rubisco small subunit (SSu) varies with environmental changes, but the functional role of any changes in expression remains unclear. In this study, we investigated the… read more here.
Keywords: rubisco; isoform expression; grown plants; warm grown ... See more keywords
Tissue‐specific expression of insulin receptor isoforms in obesity/type 2 diabetes mouse models
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DOI: 10.1111/jcmm.16452
Abstract: The two insulin receptor (IR) isoforms IR‐A and IR‐B are responsible for the pleiotropic actions of insulin and insulin‐like growth factors. Consequently, changes in IR isoform expression and in the bioavailability of their ligands will… read more here.
Keywords: isoform expression; tissue; insulin receptor; expression ... See more keywords
Modulation of Progesterone Receptor Isoform Expression in Pregnant Human Myometrium
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DOI: 10.1155/2017/4589214
Abstract: Background. Regulation of myometrial progesterone receptor (PR) expression is an unresolved issue central to understanding the mechanism of functional progesterone withdrawal and initiation of labor in women. Objectives. To determine whether pregnant human myometrium undergoes… read more here.
Keywords: isoform expression; human myometrium; expression; culture ... See more keywords
Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo
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DOI: 10.12688/wellcomeopenres.15762.2
Abstract: Background: The dystrophin gene has multiple isoforms: full-length dystrophin (dp427) is principally known for its expression in skeletal and cardiac muscle, but is also expressed in the brain, and several internal promoters give rise to… read more here.
Keywords: situ hybridisation; single transcript; isoform expression; expression ... See more keywords
Analysis of TERT Isoforms across TCGA, GTEx and CCLE Datasets
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DOI: 10.3390/cancers13081853
Abstract: Simple Summary All cancers must maintain telomere length to achieve immortality and around 80% do so by reactivating the enzyme complex telomerase. The diverse regulatory mechanisms surrounding the enzymatic component, telomerase reverse transcriptase (TERT), are… read more here.
Keywords: isoform expression; tissue; expression; tert isoform ... See more keywords
Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling
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DOI: 10.3390/v15030632
Abstract: Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple IFNLR1 transcriptional variants are expressed in vivo… read more here.
Keywords: ifnlr1; ifnlr1 isoform; expression; flag ifnlr1 ... See more keywords