A tool for analyzing and visualizing ribo-seq data at the isoform level
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04192-7
Abstract: Background Translational regulation is one important aspect of gene expression regulation. Dysregulation of translation results in abnormal cell physiology and leads to diseases. Ribosome profiling (RP), also called ribo-seq, is a powerful experimental technique to… read more here.
Keywords: isoform level; profiling data; ribosome profiling; level ... See more keywords
Extending the R Library PROPER to Enable Power Calculations for Isoform-Level Analysis with EBSeq
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2016.00225
Abstract: RNA-Sequencing (RNA-Seq) has become a routine technology for investigating gene expression differences in comparative transcriptomic studies. Differential expression (DE) analysis of the isoforms of genes is just emerging now that expression (read counts) can be… read more here.
Keywords: library proper; analysis; power; expression ... See more keywords
A conditional gene-based association framework integrating isoform-level eQTL data reveals new susceptibility genes for schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.70779
Abstract: Linkage disequilibrium and disease-associated variants in the non-coding regions make it difficult to distinguish the truly associated genes from the redundantly associated genes for complex diseases. In this study, we proposed a new conditional gene-based… read more here.
Keywords: susceptibility genes; gene; association; isoform level ... See more keywords